Journal
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Volume 119, Issue -, Pages 101-127Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2020.09.022
Keywords
Chronic pain; Pain models; Pain assessment; Anxiety; Depression; Learning and memory; Decision-making
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Funding
- IASP through the IASP Early Career Research Grant
- Foundation for Science and Technology (Fundacao para a Ciencia e a Tecnologia, FCT) [PTDC/NEU-SCC/5301/2014]
- FCT [SFRH/BD/109111/2015, PD/BD/114117/2015]
- Fundação para a Ciência e a Tecnologia [PTDC/NEU-SCC/5301/2014, SFRH/BD/109111/2015, PD/BD/114117/2015] Funding Source: FCT
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Rodent models have been fundamental to understand chronic pain (CP) pathophysiology and to test for potential treatments. Pain assessment in CP models is most frequently based on the evaluation of allodynia or hyperalgesia. However, these correspond only to a part of CP-related problems which include ongoing pain, depression, anxiety, disrupted sleep and attentional deficits. A growing number of preclinical studies have been assessing these manifestations in CP rodent models. We reviewed and systematized this information by behavioral domain. Observational studies in ethologically relevant conditions, paradigms of anxietyand depressive like behavior as well as of memory and executive function were selected. A considerable number of studies reported deficits similar to those observed in CP patients. These behavioral alterations are informative regarding ongoing maladaptive plasticity in multiple brain regions and its use as pain proxies has the potential to greatly improve the predictive value of CP models. However, the inclusion of female and/or older rodents is rare which is in clear dissonance with the clinical representation of CP.
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