Journal
NEUROMOLECULAR MEDICINE
Volume 23, Issue 1, Pages 161-175Publisher
HUMANA PRESS INC
DOI: 10.1007/s12017-020-08636-w
Keywords
Plasmalogens; Lipids; Alkyl-acyl phospholipids; Lysophospholipids; Alzheimer's disease; Prefrontal cortex
Categories
Funding
- National Institute On Aging of the National Institutes of Health [P30AG010129]
- Alzheimer's Association [2018-AARGD-591676]
- NARO Bio-oriented Technology Research Advancement Institution [1074345]
- Japan Society for the Promotion of Science
Ask authors/readers for more resources
Alzheimer's disease causes specific changes in brain phospholipids, particularly in the prefrontal cortex. The study findings indicate a significant reduction in PLs containing stearic acid and docosahexaenoic acid in AD patients, suggesting potential targets for therapeutic interventions.
Alzheimer's disease (AD) is a progressive and incurable brain disorder that has been associated with structural changes in brain phospholipids (PLs), including diacyl species and ether-linked PLs known as plasmalogens. Most studies have characterized total changes in brain PL pools (e.g., choline plasmalogens), particularly in prefrontal cortex, but detailed and quantitative information on the molecular PL species impacted by the disease is limited. In this study, we used a comprehensive mass-spectrometry method to quantify diacyl and plasmalogen species, alkyl synthetic precursors of plasmalogens, and lysophospholipid degradation products of diacyl and plasmalogen PLs, in postmortem samples of prefrontal cortex from 21 AD patients and 20 age-matched controls. Total PLs were also quantified with gas-chromatography analysis of bound fatty acids following thin layer chromatography isolation. There was a significant 27% reduction in the concentration (nmol/g wet weight) of choline plasmalogen containing stearic acid (alkenyl group) and docosahexaenoic acid in AD compared to controls. Stearic acid concentration in total PLs was reduced by 26%. Our findings suggest specific changes in PLs containing stearic acid and docosahexaenoic acid in AD prefrontal cortex, highlighting structural and turnover PL pathways that could be targeted.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available