4.7 Article

High-Frequency Oscillations in Epilepsy What Have We Learned and What Needs to be Addressed

Journal

NEUROLOGY
Volume 96, Issue 9, Pages 439-448

Publisher

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.0000000000011465

Keywords

-

Funding

  1. China Scholarship Council [201709120011]
  2. Australian National Health and Medical Research Council [1130468, 1183119]
  3. National Health and Medical Research Council of Australia [1183119, 1130468] Funding Source: NHMRC

Ask authors/readers for more resources

HFOs have been enthusiastically studied by the epilepsy community for the past 20 years, showing promise in delineating epileptogenic brain areas and predicting seizures. Despite advancements in research using automatic detection and prediction strategies, there are still significant obstacles hindering the clinical application of HFOs as biomarkers. Collaboration and further research are needed to address these challenges.
For the past 2 decades, high-frequency oscillations (HFOs) have been enthusiastically studied by the epilepsy community. Emerging evidence shows that HFOs harbor great promise to delineate epileptogenic brain areas and possibly predict the likelihood of seizures. Investigations into HFOs in clinical epilepsy have advanced from small retrospective studies relying on visual identification and correlation analysis to larger prospective assessments using automatic detection and prediction strategies. Although most studies have yielded promising results, some have revealed significant obstacles to clinical application of HFOs, thus raising debate about the reliability and practicality of HFOs as clinical biomarkers. In this review, we give an overview of the current state of HFO research and pinpoint the conceptual and methodological issues that have hampered HFO translation. We highlight recent insights gained from long-term data, high-density recordings, and multicenter collaborations and discuss the open questions that need to be addressed in future research.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available