Association between MMP16 rs60298754 and clinical phenotypes of Parkinson's disease in southern Chinese

Study objectives The aim was to investigate the association between MMP16 rs60298754 and symptoms of Parkinson's disease (PD) in southern Chinese. Methods Seven hundred forty-five PD patients were recruited in this study. All patients were evaluated by Brief Pain Inventory (BPI), Hamilton anxiety rating scale and Hamilton depression rating scale, 39-item Parkinson's disease Questionnaire (PDQ-39), and MDS-Unified PD Rating Scale (MDS-UPDRS). Symptoms were also recorded. Results The difference of BPI and Parkinson's disease sleep scale (PDSS) between two groups was showed (BPI: MMP16 wildtypes: 14.73 +/- 14.45; MMP16 carriers: 10.95 +/- 10.67, p 0.002; PDSS: MMP16 wildtypes: 117.80 +/- 21.45; MMP16 carriers: 108.40 +/- 23.95, p < 0.001). The association of apathy, nocturia, and sensitive to light were found (apathy: p 0.001, OR: 0.49, 0.32-0.76; nocturia: p < 0.001, OR: 3.57, 1.90-7.26; sensitive to light: p < 0.001, OR: 3.99, 2.01-7.74). Conclusions MMP16 rs60298754 was associated with the presence of apathy, pain, nocturia, and sensitive to light.

Automated summary

The study revealed an association between MMP16 rs60298754 and symptoms of Parkinson's disease in southern Chinese patients, including apathy, pain, nocturia, and sensitivity to light.