Journal
DOKLADY BIOCHEMISTRY AND BIOPHYSICS
Volume 467, Issue 1, Pages 132-135Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1607672916020150
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Funding
- Russian Foundation for Basic Research [14-04-31090 mol_a, 14-04-00699 A]
- Dynasty fund
- Russian Science Foundation [14-25-00056]
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The mechanism of caspase-2 activation in response to DNA damage was studied using human ovarian cancer cells Caov-4 treated with chemotherapeutic agent cisplatin. It was shown that mutations of the three cleavage sites of caspase-2 do not affect the assembly of the macromolecular complex of caspase-2 and its activation, but, conversely, stabilize this complex, most likely, via the inhibition of the dissociation of the active caspase-2.
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