Journal
NEUROCHEMICAL RESEARCH
Volume 46, Issue 2, Pages 379-395Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-020-03174-0
Keywords
Apoptosis; Curcumin; Inflammation; Paclitaxel; Peripheral neurotoxicity
Categories
Ask authors/readers for more resources
The study demonstrated that curcumin has protective effects against paclitaxel-induced spinal cord and sciatic nerve injuries in rats, by reducing inflammation, inhibiting apoptotic and autophagic pathways activation, and maintaining the integrity of neural tissue structure.
Paclitaxel (PTX) is an antineoplastic agent commonly used in the treatment of solid tumors and is known to cause dose-limiting peripheral neurotoxicity. This study was performed to evaluate the protective effect of curcumin (CUR) against PTX-induced spinal cord and sciatic nerve injuries in rats. The rats were administered PTX (2 mg/kg, BW) intraperitoneally for the first 5 consecutive days followed by administration of CUR (100 and 200 mg/kg, BW daily in corn oil) orally for 10 days. Our results showed that CUR significantly reduced mRNA expression levels of NF-kappa B, TNF-alpha, IL-6, iNOS and GFAP whereas caused an increase in levels of Nrf2, HO-1 and NQO1 in the spinal cord and sciatic nerve of PTX-induced rats. In addition, CUR suppressed the activation of apoptotic and autophagic pathways by increasing Bcl-2 and Bcl-xL, and decreasing p53, caspase-3, Apaf-1, LC3A, LC3B and beclin-1 mRNA expression levels. The results showed that CUR also maintained the spinal cord and sciatic nerve histological architecture and integrity by both LFB staining and H&E staining. Immunohistochemical expressions of 8-OHdG, caspase-3 and LC3B in the PTX-induced spinal cord tissue were decreased after administration of CUR. Taken together, our findings demonstrated that CUR has protective effects on PTX-induced spinal cord and sciatic nerve injuries in rats.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available