Journal
NEUROCHEMICAL RESEARCH
Volume 46, Issue 1, Pages 77-87Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-020-03208-7
Keywords
Reactive species; ROS; Hormesis; Homeostasis
Categories
Funding
- King Abdullah University of Science and Technology
Ask authors/readers for more resources
Cellular homeostasis is crucial for organism development and aging, with disruption leading to health degradation and death. Reactive oxygen species (ROS) are strongly linked to health decline and neurological disorders, disrupting macromolecules and playing complex roles in cell signaling, particularly in the brain where they impact neuronal survival and synaptic plasticity.
Cellular homeostasis plays a critical role in how an organism will develop and age. Disruption of this fragile equilibrium is often associated with health degradation and ultimately, death. Reactive oxygen species (ROS) have been closely associated with health decline and neurological disorders, such as Alzheimer's disease or Parkinson's disease. ROS were first identified as by-products of the cellular activity, mainly mitochondrial respiration, and their high reactivity is linked to a disruption of macromolecules such as proteins, lipids and DNA. More recent research suggests more complex function of ROS, reaching far beyond the cellular dysfunction. ROS are active actors in most of the signaling cascades involved in cell development, proliferation and survival, constituting important second messengers. In the brain, their impact on neurons and astrocytes has been associated with synaptic plasticity and neuron survival. This review provides an overview of ROS function in cell signaling in the context of aging and degeneration in the brain and guarding the fragile balance between health and disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available