Journal
DNA REPAIR
Volume 38, Issue -, Pages 84-93Publisher
ELSEVIER
DOI: 10.1016/j.dnarep.2015.11.024
Keywords
Meiosis; Crossing over; Msh4-Msh5; Mlh1-Mlh3; Holliday junction resolution
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Funding
- National Institute of General Medical Sciences of the National Institutes of Health [GM53085]
- NIH [F32 GM112435]
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The mismatch repair (MMR) family complexes Msh4-Msh5 and Mlh1-Mlh3 act with Exo1 and Sgs1-Top3-Rmi1 in a meiotic double strand break repair pathway that results in the asymmetric cleavage of double Holliday junctions (dHJ) to form crossovers. This review discusses how meiotic roles for Msh4-Msh5 and Mlh1-Mlh3 do not fit paradigms established for post-replicative MMR. We also outline models used to explain how these factors promote the formation of meiotic crossovers required for the accurate segregation of chromosome homologs during the Meiosis I division. (C) 2015 Elsevier B.V. All rights reserved.
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