Solutes as controllers of endomembrane dynamics

Membrane dynamics, such as those associated with intracellular traffic, require controlled deformation of the membrane. There is now evidence that the regulation of the luminal fluid composition - via solute fluxes - prominently impacts dynamic properties of endomembranes by modulating their tension. This has important consequences for the function of the endo-lysosomal system. Spencer Freeman draws attention to the role of ion fluxes and vesicular solute composition in regulating dynamics of endomembranes.

Automated summary

Controlled deformation of membranes is necessary for membrane dynamics, especially in intracellular traffic. Luminal fluid composition and solute fluxes have a significant impact on the dynamic properties of endomembranes by modulating their tension, which in turn affects the function of the endo-lysosomal system. Spencer Freeman emphasizes the role of ion fluxes and vesicular solute composition in regulating the dynamics of endomembranes.