Journal
DNA REPAIR
Volume 38, Issue -, Pages 14-23Publisher
ELSEVIER
DOI: 10.1016/j.dnarep.2015.11.012
Keywords
MutS; MutL; MutH; Structure conservation
Categories
Funding
- NWO-CW
- EU MM2M
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The machinery of DNA mismatch repair enzymes is highly conserved in evolution. The process is initiated by recognition of a DNA mismatch, and validated by ATP and the presence of a processivity clamp or a methylation mark. Several events in MMR promote conformational changes that lead to progression of the repair process. Here we discuss functional conformational changes in the MMR proteins and we compare the enzymes to paralogs in other systems. (C) 2015 The Authors. Published by Elsevier B.V.
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