4.6 Review

Cellular and molecular pathobiology of heart failure with preserved ejection fraction

Related references

Note: Only part of the references are listed.
Article Cardiac & Cardiovascular Systems

Myocardial Gene Expression Signatures in Human Heart Failure With Preserved Ejection Fraction

Virginia S. Hahn et al.

Summary: The study revealed distinctive transcriptomic signatures and molecular subgroupings in patients with HFpEF, with specific clinical features and outcomes. Obesity was found to be a major contributor to the upregulation of genes in HFpEF, while pathways related to endoplasmic reticulum stress, autophagy, and angiogenesis were identified as downregulated genes specific to HFpEF.

CIRCULATION (2021)

Article Cardiac & Cardiovascular Systems

Pulmonary hypertension and right ventricular remodeling in HFpEF and HFrEF

Stefano Ghio et al.

HEART FAILURE REVIEWS (2020)

Editorial Material Cardiac & Cardiovascular Systems

Optimizing The Management of Obese HFpEF Phenotype: Can We Mind Both The Heart and The Kidney?

Bharathi Upadhya et al.

JOURNAL OF CARDIAC FAILURE (2020)

Review Cardiac & Cardiovascular Systems

Myocardial Phosphodiesterases and Their Role in cGMP Regulation

Brittany Dunkerly-Eyring et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Prior Heart Failure Hospitalization, Clinical Outcomes, and Response to Sacubitril/Valsartan Compared With Valsartan in HFpEF

Muthiah Vaduganathan et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

Review Pharmacology & Pharmacy

IL-11 in cardiac and renal fibrosis: Late to the party but a central player

Benjamin Corden et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Endothelium-dependent and independent coronary microvascular dysfunction in patients with heart failure with preserved ejection fraction

Jeong Hoon Yang et al.

EUROPEAN JOURNAL OF HEART FAILURE (2020)

Article Cardiac & Cardiovascular Systems

Site-specific acetyl-mimetic modification of cardiac troponin I modulates myofilament relaxation and calcium sensitivity

Ying H. Lin et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2020)

Editorial Material Medicine, General & Internal

Unfolding Discoveries in Heart Failure

Walter J. Paulus

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Cardiac & Cardiovascular Systems

A new algorithm for optimization of rate-adaptive pacing improves exercise tolerance in patients with HFpEF

Maria Serova et al.

PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY (2020)

Article Cell Biology

HDAC inhibition improves cardiopulmonary function in a feline model of diastolic dysfunction

Markus Wallner et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

Article Cardiac & Cardiovascular Systems

Covariate adjusted reanalysis of the I-Preserve trial

Joao Pedro Ferreira et al.

CLINICAL RESEARCH IN CARDIOLOGY (2020)

Review Cardiac & Cardiovascular Systems

Therapeutic approaches in heart failure with preserved ejection fraction: past, present, and future

Jan Wintrich et al.

CLINICAL RESEARCH IN CARDIOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Multiple Plasma Biomarkers for Risk Stratification in Patients With Heart Failure and Preserved Ejection Fraction

Julio A. Chirinos et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Extended-Release Oral Milrinone for the Treatment of Heart Failure With Preserved Ejection Fraction

Shane Nanayakkara et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2020)

Article Medicine, General & Internal

Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure

Milton Packer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Cardiac & Cardiovascular Systems

Estrogen Receptor-α Non-Nuclear Signaling Confers Cardioprotection and Is Essential to cGMP-PDE5 Inhibition Efficacy

Nobuaki Fukuma et al.

JACC-BASIC TO TRANSLATIONAL SCIENCE (2020)

Article Cardiac & Cardiovascular Systems

Peripheral Determinants of Oxygen Utilization in Heart Failure With Preserved Ejection Fraction Central Role of Adiposity

Payman Zamani et al.

JACC-BASIC TO TRANSLATIONAL SCIENCE (2020)

Article Cardiac & Cardiovascular Systems

Heart failure with preserved ejection fraction in Asia

Jasper Tromp et al.

EUROPEAN JOURNAL OF HEART FAILURE (2019)

Review Cardiac & Cardiovascular Systems

CaMKII signaling in heart diseases: Emerging role in diabetic cardiomyopathy

Bence Hegyi et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2019)

Review Cardiac & Cardiovascular Systems

Heart Failure With Preserved Ejection Fraction and Diabetes JACC State-of-the-Art Review

Kelly McHugh et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2019)

Article Cardiac & Cardiovascular Systems

Combining Circulating MicroRNA and NT-proBNP to Detect and Categorize Heart Failure Subtypes

Lee Lee Wong et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2019)

Article Multidisciplinary Sciences

PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress

Mark J. Ranek et al.

NATURE (2019)

Article Urology & Nephrology

The Impact of APOL1 on Chronic Kidney Disease and Hypertension

Todd W. Robinson et al.

ADVANCES IN CHRONIC KIDNEY DISEASE (2019)

Review Cardiac & Cardiovascular Systems

Cardiorenal syndrome in heart failure with preserved ejection fractionan under-recognized clinical entity

Akanksha Agrawal et al.

HEART FAILURE REVIEWS (2019)

Article Cardiac & Cardiovascular Systems

Pulmonary vascular disease in the setting of heart failure with preserved ejection fraction

Andrea R. Levine et al.

TRENDS IN CARDIOVASCULAR MEDICINE (2019)

Review Cardiac & Cardiovascular Systems

Exercise Intolerance in Patients With Heart Failure

Marco Giuseppe Del Buono et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2019)

Article Multidisciplinary Sciences

Nitrosative stress drives heart failure with preserved ejection fraction

Gabriele G. Schiattarella et al.

NATURE (2019)

Article Multidisciplinary Sciences

In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease

Brian Leei Lin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Cardiac & Cardiovascular Systems

Arterial Remodeling and Dysfunction in the ZSF1 Rat Model of Heart Failure With Preserved Ejection Fraction

Sara Leite et al.

CIRCULATION-HEART FAILURE (2019)

Article Cardiac & Cardiovascular Systems

Rationale and design of the EMPERIAL-Preserved and EMPERIAL-Reduced trials of empagliflozin in patients with chronic heart failure

William T. Abraham et al.

EUROPEAN JOURNAL OF HEART FAILURE (2019)

Review Cardiac & Cardiovascular Systems

Inflammation in nonischemic heart disease: initiation by cardiomyocyte CaMKII and NLRP3 inflammasome signaling

Takeshi Suetomi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2019)

Review Biochemistry & Molecular Biology

CaMKII Activity in the Inflammatory Response of Cardiac Diseases

Maria Rosaria Rusciano et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Medicine, General & Internal

Angiotensin-Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction

S. D. Solomon et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Cardiac & Cardiovascular Systems

Myocardial Energetics in Heart Failure With Preserved Ejection Fraction

Omar F. AbouEzzeddine et al.

CIRCULATION-HEART FAILURE (2019)

Review Peripheral Vascular Disease

Is Heart Failure with Preserved Ejection Fraction a Kidney Disorder?

Kevin S. Shah et al.

CURRENT HYPERTENSION REPORTS (2019)

Review Biochemistry & Molecular Biology

Mitochondrial NAD+/NADH Redox State and Diabetic Cardiomyopathy

Jessica M. Berthiaume et al.

ANTIOXIDANTS & REDOX SIGNALING (2019)

Review Physiology

Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction

Domenico D'Amario et al.

FRONTIERS IN PHYSIOLOGY (2019)

Review Physiology

Metabolic Profiling of the Diabetic Heart: Toward a Richer Picture

Alice P. Sowton et al.

FRONTIERS IN PHYSIOLOGY (2019)

Review Cardiac & Cardiovascular Systems

Microvascular Rarefaction and Heart Failure With Preserved Ejection Fraction

Heng Zeng et al.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2019)

Article Cardiac & Cardiovascular Systems

Coronary microvascular dysfunction and future risk of heart failure with preserved ejection fraction

Viviany R. Taqueti et al.

EUROPEAN HEART JOURNAL (2018)

Article Medicine, General & Internal

Effect of Spironolactone on Myocardial Fibrosis and Other Clinical Variables in Patients with Hypertrophic Cardiomyopathy

Martin S. Maron et al.

AMERICAN JOURNAL OF MEDICINE (2018)

Article Cardiac & Cardiovascular Systems

Characterization of a mouse model of obesity-related fibrotic cardiomyopathy that recapitulates features of human heart failure with preserved ejection fraction

Linda Alex et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2018)

Article Cardiac & Cardiovascular Systems

A Simple, Evidence-Based Approach to Help Guide Diagnosis of Heart Failure With Preserved Ejection Fraction

Yogesh N. V. Reddy et al.

CIRCULATION (2018)

Review Cardiac & Cardiovascular Systems

Diabetic Cardiomyopathy: An Update of Mechanisms Contributing to This Clinical Entity

Guanghong Jia et al.

CIRCULATION RESEARCH (2018)

Review Cardiac & Cardiovascular Systems

Mechanisms of the Improvement in Peak VO2 With Exercise Training in Heart Failure With Reduced or Preserved Ejection Fraction

Wesley J. Tucker et al.

HEART LUNG AND CIRCULATION (2018)

Article Cardiac & Cardiovascular Systems

Captopril Attenuates Cardiovascular and Renal Disease in a Rat Model of Heart Failure With Preserved Ejection Fraction

Eman M. Salah et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2018)

Editorial Material Cardiac & Cardiovascular Systems

Dynamics of fibroblast activation in the infarcted heart

Alexandra Le Bras

NATURE REVIEWS CARDIOLOGY (2018)

Article Medicine, Research & Experimental

Defining the molecular signatures of human right heart failure

Jordan L. Williams et al.

LIFE SCIENCES (2018)

Review Cardiac & Cardiovascular Systems

Nitric oxide signalling in cardiovascular health and disease

Charlotte Farah et al.

NATURE REVIEWS CARDIOLOGY (2018)

Review Cardiac & Cardiovascular Systems

Mechanisms of physiological and pathological cardiac hypertrophy

Michinari Nakamura et al.

NATURE REVIEWS CARDIOLOGY (2018)

Review Pharmacology & Pharmacy

Cardiac metabolism - A promising therapeutic target for heart failure

Hannah Noordali et al.

PHARMACOLOGY & THERAPEUTICS (2018)

Article Cell Biology

Histone deacetylase activity governs diastolic dysfunction through a nongenomic mechanism

Mark Y. Jeong et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

Review Medicine, Research & Experimental

Heart Failure with Preserved Ejection Fraction

James D. Gladden et al.

ANNUAL REVIEW OF MEDICINE, VOL 69 (2018)

Article Cardiac & Cardiovascular Systems

Pro-Inflammatory Biomarkers in Stable Versus Acutely Decompensated Heart Failure With Preserved Ejection Fraction

Abraham Abernethy et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2018)

Article Cardiac & Cardiovascular Systems

Association of APOL1 With Heart Failure With Preserved Ejection Fraction in Postmenopausal African American Women

Nora Franceschini et al.

JAMA CARDIOLOGY (2018)

Article Cardiac & Cardiovascular Systems

Association of Cardiovascular Biomarkers With Incident Heart Failure With Preserved and Reduced Ejection Fraction

Rudolf A. de Boer et al.

JAMA CARDIOLOGY (2018)

Article Cardiac & Cardiovascular Systems

Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy

Nicolas Diguet et al.

CIRCULATION (2018)

Article Cardiac & Cardiovascular Systems

IL-1 Blockade in Patients With Heart Failure With Preserved Ejection Fraction: Results From DHART2

Benjamin W. Van Tassell et al.

CIRCULATION-HEART FAILURE (2018)

Article Multidisciplinary Sciences

High-sensitivity C-reactive protein in heart failure with preserved ejection fraction

Hilary M. DuBrock et al.

PLOS ONE (2018)

Article Medicine, Research & Experimental

Plasma levels of heart failure biomarkers are primarily a reflection of extracardiac production

Weijie Du et al.

THERANOSTICS (2018)

Editorial Material Cardiac & Cardiovascular Systems

Weighty Matters in HFpEF and Aging

Daniel E. Forman et al.

JACC-HEART FAILURE (2018)

Review Cardiac & Cardiovascular Systems

Loss of Metabolic Flexibility in the Failing Heart

Qutuba G. Karwi et al.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2018)

Article Medicine, Research & Experimental

Diabetes with heart failure increases methylglyoxal modifications in the sarcomere, which inhibit function

Maria Papadaki et al.

JCI INSIGHT (2018)

Article Medicine, Research & Experimental

Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart

Xing Fu et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Cardiac & Cardiovascular Systems

CCR2+ Monocyte-Derived Infiltrating Macrophages Are Required for Adverse Cardiac Remodeling During Pressure Overload

Bindiya Patel et al.

JACC-BASIC TO TRANSLATIONAL SCIENCE (2018)

Article Cardiac & Cardiovascular Systems

Effect of ivabradine in patients with heart failure with preserved ejection fraction: the EDIFY randomized placebo-controlled trial

Michel Komajda et al.

EUROPEAN JOURNAL OF HEART FAILURE (2017)

Review Medicine, Research & Experimental

Skeletal muscle inflammation and insulin resistance in obesity

Huaizhu Wu et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Article Cardiac & Cardiovascular Systems

Endothelial specific SIRT3 deletion impairs glycolysis and angiogenesis and causes diastolic dysfunction

Xiaochen He et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2017)

Article Endocrinology & Metabolism

The diabetic heart utilizes ketone bodies as an energy source

Yuji Mizuno et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2017)

Letter Medicine, General & Internal

Spironolactone Metabolites in TOPCAT - New Insights into Regional Variation

Simon de Denus et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Review Pharmacology & Pharmacy

Cardiac oxidative stress in diabetes: Mechanisms and therapeutic potential

Alyssa Faria et al.

PHARMACOLOGY & THERAPEUTICS (2017)

Article Multidisciplinary Sciences

T cell costimulation blockade blunts pressure overload-induced heart failure

Marinos Kallikourdis et al.

NATURE COMMUNICATIONS (2017)

Review Cardiac & Cardiovascular Systems

Heart Failure with Preserved Ejection Fraction and Future Pharmacological Strategies: a Glance in the Crystal Ball

Carsten Tschoepe et al.

CURRENT CARDIOLOGY REPORTS (2017)

Article Cardiac & Cardiovascular Systems

Percutaneous Pericardial Resection A Novel Potential Treatment for Heart Failure With Preserved Ejection Fraction

Barry A. Borlaug et al.

CIRCULATION-HEART FAILURE (2017)

Review Cardiac & Cardiovascular Systems

Effect of bariatric surgery on heart failure

Marcela Rodriguez Flores et al.

EXPERT REVIEW OF CARDIOVASCULAR THERAPY (2017)

Article Cardiac & Cardiovascular Systems

Fatigability, Exercise Intolerance, and Abnormal Skeletal Muscle Energetics in Heart Failure

Kilian Weiss et al.

CIRCULATION-HEART FAILURE (2017)

Article Cardiac & Cardiovascular Systems

Growth differentiation factor 15 in heart failure with preserved vs. reduced ejection fraction

Michelle M. Y. Chan et al.

EUROPEAN JOURNAL OF HEART FAILURE (2016)

Article Cardiac & Cardiovascular Systems

Evidence of microvascular dysfunction in heart failure with preserved ejection fraction

Joshua F. Lee et al.

HEART (2016)

Article Cardiac & Cardiovascular Systems

Diagnostic significance of serum galectin-3 levels in heart failure with preserved ejection fraction

Veli Polat et al.

ACTA CARDIOLOGICA (2016)

Article Cardiac & Cardiovascular Systems

Myocardial steatosis as a possible mechanistic link between diastolic dysfunction and coronary microvascular dysfunction in women

Janet Wei et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2016)

Review Cardiac & Cardiovascular Systems

Atrial remodelling in atrial fibrillation: CaMKII as a nodal proarrhythmic signal

Olurotimi O. Mesubi et al.

CARDIOVASCULAR RESEARCH (2016)

Article Cardiac & Cardiovascular Systems

Normalization of NAD+ Redox Balance as a Therapy for Heart Failure

Chi Fung Lee et al.

CIRCULATION (2016)

Article Cardiac & Cardiovascular Systems

The Failing Heart Relies on Ketone Bodies as a Fuel

Gregory Aubert et al.

CIRCULATION (2016)

Article Endocrinology & Metabolism

CV Protection in the EMPA-REG OUTCOME Trial: A Thrifty Substrate Hypothesis

Ele Ferrannini et al.

DIABETES CARE (2016)

Article Cardiac & Cardiovascular Systems

Abnormal right ventricular-pulmonary artery coupling with exercise in heart failure with preserved ejection fraction

Barry A. Borlaug et al.

EUROPEAN HEART JOURNAL (2016)

Article Cardiac & Cardiovascular Systems

Novel pathomechanisms of cardiomyocyte dysfunction in a model of heart failure with preserved ejection fraction

Uwe Primessnig et al.

EUROPEAN JOURNAL OF HEART FAILURE (2016)

Article Biochemistry & Molecular Biology

Redox signaling in the cardiomyocyte: From physiology to failure

Celio X. C. Santos et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2016)

Article Cardiac & Cardiovascular Systems

Vascular and Microvascular Endothelial Function in Heart Failure With Preserved Ejection Fraction

Sylvestre Marechaux et al.

JOURNAL OF CARDIAC FAILURE (2016)

Letter Cardiac & Cardiovascular Systems

Effects of Milrinone on Rest and Exercise Hemodynamics in Heart Failure With Preserved Ejection Fraction

David M. Kaye et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2016)

Editorial Material Cardiac & Cardiovascular Systems

The HFpEF Obesity Phenotype The Elephant in the Room

Dalane W. Kitzman et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2016)

Article Cardiac & Cardiovascular Systems

Impaired Pulmonary Diffusion in Heart Failure With Preserved Ejection Fraction

Thomas P. Olson et al.

JACC-HEART FAILURE (2016)

Article Cardiac & Cardiovascular Systems

Myocardial Microvascular Inflammatory Endothelial Activation in Heart Failure With Preserved Ejection Fraction

Constantijn Franssen et al.

JACC-HEART FAILURE (2016)

Article Pharmacology & Pharmacy

A Soluble Guanylate Cyclase Activator Inhibits the Progression of Diabetic Nephropathy in the ZSF1 Rat

Carine M. Boustany-Kari et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2016)

Article Cardiac & Cardiovascular Systems

Early-stage heart failure with preserved ejection fraction in the pig: a cardiovascular magnetic resonance study

Ursula Reiter et al.

JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE (2016)

Review Cardiac & Cardiovascular Systems

Exercise training in chronic heart failure: improving skeletal muscle O2 transport and utilization

Daniel M. Hirai et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2015)

Article Cardiac & Cardiovascular Systems

A porcine model of hypertensive cardiomyopathy: implications for heart failure with preserved ejection fraction

Michael Schwarzl et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2015)

Review Pharmacology & Pharmacy

The cGMP/PKG pathway as a common mediator of cardioprotection: translatability and mechanism

Javier Inserte et al.

BRITISH JOURNAL OF PHARMACOLOGY (2015)

Review Cardiac & Cardiovascular Systems

Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction

Thenappan Thenappan et al.

CANADIAN JOURNAL OF CARDIOLOGY (2015)

Article Cardiac & Cardiovascular Systems

Effect of Selective Heart Rate Slowing in Heart Failure With Preserved Ejection Fraction

Nikhil Pal et al.

CIRCULATION (2015)

Article Cardiac & Cardiovascular Systems

Circulating biomarkers of distinct pathophysiological pathways in heart failure with preserved vs. reduced left ventricular ejection fraction

Sandra Sanders-van Wijk et al.

EUROPEAN JOURNAL OF HEART FAILURE (2015)

Article Cardiac & Cardiovascular Systems

Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction

Lee Lee Wong et al.

EUROPEAN JOURNAL OF HEART FAILURE (2015)

Article Multidisciplinary Sciences

Myocardial pressure overload induces systemic inflammation through endothelial cell IL-33

Wei-Yu Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Multidisciplinary Sciences

Metabolomic Fingerprint of Heart Failure with Preserved Ejection Fraction

Beshay N. Zordoky et al.

PLOS ONE (2015)

Article Cardiac & Cardiovascular Systems

Exercise Training in Patients With Heart Failure and Preserved Ejection Fraction Meta-Analysis of Randomized Control Trials

Ambarish Pandey et al.

CIRCULATION-HEART FAILURE (2015)

Article Cardiac & Cardiovascular Systems

Coronary Microvascular Rarefaction and Myocardial Fibrosis in Heart Failure With Preserved Ejection Fraction

Selma F. Mohammed et al.

CIRCULATION (2015)

Article Cardiac & Cardiovascular Systems

Skeletal Muscle Composition and Its Relation to Exercise Intolerance in Older Patients With Heart Failure and Preserved Ejection Fraction

Mark J. Haykowsky et al.

AMERICAN JOURNAL OF CARDIOLOGY (2014)

Article Cardiac & Cardiovascular Systems

Skeletal muscle abnormalities and exercise intolerance in older patients with heart failure and preserved ejection fraction

Dalane W. Kitzman et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2014)

Article Cardiac & Cardiovascular Systems

CD4+ T Cells Promote the Transition From Hypertrophy to Heart Failure During Chronic Pressure Overload

Fanny Laroumanie et al.

CIRCULATION (2014)

Article Cardiac & Cardiovascular Systems

Right Ventricular Function in Heart Failure With Preserved Ejection Fraction A Community-Based Study

Selma F. Mohammed et al.

CIRCULATION (2014)

Article Cardiac & Cardiovascular Systems

Left Ventricular Mass and Hypertrophy by Echocardiography and Cardiac Magnetic Resonance: The Multi-Ethnic Study of Atherosclerosis

Anderson C. Armstrong et al.

ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES (2014)

Article Cardiac & Cardiovascular Systems

Right heart dysfunction in heart failure with preserved ejection fraction

Vojtech Melenovsky et al.

EUROPEAN HEART JOURNAL (2014)

Article Medicine, Research & Experimental

PDE5 inhibitor efficacy is estrogen dependent in female heart disease

Hideyuki Sasaki et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Cardiac & Cardiovascular Systems

Cardiovascular Phenotype in HFpEF Patients With or Without Diabetes A RELAX Trial Ancillary Study

Brian R. Lindman et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2014)

Review Endocrinology & Metabolism

A heart-adipose tissue connection in the regulation of energy metabolism

Sheila Collins

NATURE REVIEWS ENDOCRINOLOGY (2014)

Article Medicine, General & Internal

Spironolactone for Heart Failure with Preserved Ejection Fraction

Bertram Pitt et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Medicine, General & Internal

Angiotensin-Neprilysin Inhibition versus Enalapril in Heart Failure

John J. V. McMurray et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Review Endocrinology & Metabolism

Ketone bodies as signaling metabolites

John C. Newman et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2014)

Article Cardiac & Cardiovascular Systems

Preconditioning with soluble guanylate cyclase activation prevents postischemic inflammation and reduces nitrate tolerance in heme oxygenase-1 knockout mice

Walter Z. Wang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2013)

Review Biochemistry & Molecular Biology

Targeting mitochondrial oxidative metabolism as an approach to treat heart failure

Natasha Fillmore et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)

Article Cardiac & Cardiovascular Systems

Protein Kinase G Positively Regulates Proteasome-Mediated Degradation of Misfolded Proteins

Mark J. Ranek et al.

CIRCULATION (2013)

Review Cardiac & Cardiovascular Systems

Cardiac Metabolism in Heart Failure Implications Beyond ATP Production

Torsten Doenst et al.

CIRCULATION RESEARCH (2013)

Review Cardiac & Cardiovascular Systems

Mechanisms of Altered Ca2+ Handling in Heart Failure

Min Luo et al.

CIRCULATION RESEARCH (2013)

Article Cardiac & Cardiovascular Systems

Plasma Free Fatty Acids and Risk of Heart Failure The Cardiovascular Health Study

Luc Djousse et al.

CIRCULATION-HEART FAILURE (2013)

Article Cardiac & Cardiovascular Systems

Effects of carvedilol on heart failure with preserved ejection fraction: the Japanese Diastolic Heart Failure Study (J-DHF)

Kazuhiro Yamamoto et al.

EUROPEAN JOURNAL OF HEART FAILURE (2013)

Review Cardiac & Cardiovascular Systems

Galectin-3 in heart failure with preserved ejection fraction

Rudolf A. de Boer et al.

EUROPEAN JOURNAL OF HEART FAILURE (2013)

Article Biochemistry & Molecular Biology

Increased cGMP promotes healthy expansion and browning of white adipose tissue

Michaela M. Mitschke et al.

FASEB JOURNAL (2013)

Article Medicine, General & Internal

Effect of Phosphodiesterase-5 Inhibition on Exercise Capacity and Clinical Status in Heart Failure With Preserved Ejection Fraction A Randomized Clinical Trial

Margaret M. Redfield et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2013)

Article Cardiac & Cardiovascular Systems

Metabolic effects of glutamine on the heart: Anaplerosis versus the hexosamine biosynthetic pathway

Benjamin Lauzier et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2013)

Article Geriatrics & Gerontology

Impaired Aerobic Capacity and Physical Functional Performance in Older Heart Failure Patients With Preserved Ejection Fraction: Role of Lean Body Mass

Mark J. Haykowsky et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2013)

Article Cardiac & Cardiovascular Systems

Biomarkers in acutely decompensated heart failure with preserved or reduced ejection fraction

Kalkidan Bishu et al.

AMERICAN HEART JOURNAL (2012)

Article Cardiac & Cardiovascular Systems

Low Myocardial Protein Kinase G Activity in Heart Failure With Preserved Ejection Fraction

Loek van Heerebeek et al.

CIRCULATION (2012)

Article Cardiac & Cardiovascular Systems

Increased Proximal Arterial Stiffness and Cardiac Response With Moderate Exercise in Patients With Heart Failure and Preserved Ejection Fraction

Lamia Tartiere-Kesri et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2012)

Article Multidisciplinary Sciences

CaMKII determines mitochondrial stress responses in heart

Mei-ling A. Joiner et al.

NATURE (2012)

Article Cardiac & Cardiovascular Systems

Deletion of Cardiomyocyte Mineralocorticoid Receptor Ameliorates Adverse Remodeling After Myocardial Infarction

Daniela Fraccarollo et al.

CIRCULATION (2011)

Article Biochemistry & Molecular Biology

HDAC3-dependent Reversible Lysine Acetylation of Cardiac Myosin Heavy Chain Isoforms Modulates Their Enzymatic and Motor Activity

Sadhana A. Samant et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Cardiac & Cardiovascular Systems

Decreased Cardiac Functional Reserve in Heart Failure With Preserved Systolic Function

Holly S. Norman et al.

JOURNAL OF CARDIAC FAILURE (2011)

Article Cardiac & Cardiovascular Systems

High-carbohydrate High-fat Diet-induced Metabolic Syndrome and Cardiovascular Remodeling in Rats

Sunil K. Panchal et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2011)

Review Cardiac & Cardiovascular Systems

CaMKII in myocardial hypertrophy and heart failure

Mark E. Anderson et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2011)

Article Cardiac & Cardiovascular Systems

Diastolic Tissue Doppler Indexes Correlate With the Degree of Collagen Expression and Cross-Linking in Heart Failure and Normal Ejection Fraction

Mario Kasner et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2011)

Article Cardiac & Cardiovascular Systems

Early development of intracellular calcium cycling defects in intact hearts of spontaneously hypertensive rats

Sunil Kapur et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2010)

Article Cardiac & Cardiovascular Systems

Impaired Heart Rate Recovery and Chronotropic Incompetence in Patients With Heart Failure With Preserved Ejection Fraction

Thanh Trung Phan et al.

CIRCULATION-HEART FAILURE (2010)

Article Cardiac & Cardiovascular Systems

Analysis of Metabolic Remodeling in Compensated Left Ventricular Hypertrophy and Heart Failure

Takao Kato et al.

CIRCULATION-HEART FAILURE (2010)

Article Biochemistry & Molecular Biology

Exogenous NAD Blocks Cardiac Hypertrophic Response via Activation of the SIRT3-LKB1-AMP-activated Kinase Pathway

Vinodkumar B. Pillai et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Cardiac & Cardiovascular Systems

Global Cardiovascular Reserve Dysfunction in Heart Failure With Preserved Ejection Fraction

Barry A. Borlaug et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2010)

Review Physiology

Myocardial Fatty Acid Metabolism in Health and Disease

Gary D. Lopaschuk et al.

PHYSIOLOGICAL REVIEWS (2010)

Review Pharmacology & Pharmacy

cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action

Sharron H. Francis et al.

PHARMACOLOGICAL REVIEWS (2010)

Article Cardiac & Cardiovascular Systems

Protein Kinase G Modulates Human Myocardial Passive Stiffness by Phosphorylation of the Titin Springs

Martina Krueger et al.

CIRCULATION RESEARCH (2009)

Article Cardiac & Cardiovascular Systems

Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction A Community-Based Study

Carolyn S. P. Lam et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2009)

Article Biochemistry & Molecular Biology

Cyclic GMP Kinase and RhoA Ser188 Phosphorylation Integrate Pro- and Antifibrotic Signals in Blood Vessels

Naoki Sawada et al.

MOLECULAR AND CELLULAR BIOLOGY (2009)

Article Biochemistry & Molecular Biology

A redox-dependent pathway for regulating class IIHDACs and cardiac hypertrophy

Tetsuro Ago et al.

Article Cardiac & Cardiovascular Systems

Hypertension-induced remodeling of cardiac excitation-contraction coupling in ventricular myocytes occurs prior to hypertrophy development

Ye Chen-Izu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2007)

Article Cardiac & Cardiovascular Systems

Impact of arterial load and loading sequence on left ventricular tissue velocities in humans

Barry A. Borlaug et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2007)

Review Peripheral Vascular Disease

Role of oxidative stress in cardiac hypertrophy and remodeling

Eiki Takimoto et al.

HYPERTENSION (2007)

Article Medicine, Research & Experimental

TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling

Koichiro Kuwahara et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

Article Medicine, General & Internal

Trends in prevalence and outcome of heart failure with preserved ejection fraction

Theophilus E. Owan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

Article Cardiac & Cardiovascular Systems

Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy

Yongli Kong et al.

CIRCULATION (2006)

Article Cardiac & Cardiovascular Systems

Myocardial structure and function differ in systolic and diastolic heart failure

L van Heerebeek et al.

CIRCULATION (2006)

Article Biochemistry & Molecular Biology

Selective loss of fine tuning of Gq/11 signaling by RGS2 protein exacerbates cardiomyocyte hypertrophy

W Zhang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Pharmacology & Pharmacy

Beneficial effect of candesartan on rat diastolic heart failure

R Wake et al.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2005)

Article Cardiac & Cardiovascular Systems

Dynamics of flow velocities in endocardial and epicardial coronary arterioles

E Toyota et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2005)

Article Peripheral Vascular Disease

Is plasma cardiotrophin-1 a marker of hypertensive heart disease?

B López et al.

JOURNAL OF HYPERTENSION (2005)

Article Cardiac & Cardiovascular Systems

Cardiomyocyte stiffness in Diastolic heart failure

A Borbély et al.

CIRCULATION (2005)

Article Biochemistry & Molecular Biology

Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy

E Takimoto et al.

NATURE MEDICINE (2005)

Article Cardiac & Cardiovascular Systems

Paradoxical downregulation of the glucose oxidation pathway despite enhanced flux in severe heart failure

B Lei et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2004)

Article Cardiac & Cardiovascular Systems

Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy

VG Dávila-Román et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2002)

Article Biochemistry & Molecular Biology

cGMP-dependent protein kinase phosphorylates and inactivates RhoA

N Sawada et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)

Review Physiology

Physiology of nitric oxide in skeletal muscle

JS Stamler et al.

PHYSIOLOGICAL REVIEWS (2001)

Article Cardiac & Cardiovascular Systems

Roles of renin-angiotensin and endothelin systems in development of diastolic heart failure in hypertensive hearts

K Yamamoto et al.

CARDIOVASCULAR RESEARCH (2000)

Article Urology & Nephrology

Renal function and structure in diabetic, hypertensive, obese ZDFxSHHF-hybrid rats

SP Tofovic et al.

RENAL FAILURE (2000)