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CD4+ T Cells Promote the Transition From Hypertrophy to Heart Failure During Chronic Pressure Overload
Fanny Laroumanie et al.
CIRCULATION (2014)
Right Ventricular Function in Heart Failure With Preserved Ejection Fraction A Community-Based Study
Selma F. Mohammed et al.
CIRCULATION (2014)
Resting Ventricular-Vascular Function and Exercise Capacity in Heart Failure With Preserved Ejection Fraction A RELAX Trial Ancillary Study
Selma F. Mohammed et al.
CIRCULATION-HEART FAILURE (2014)
Left Ventricular Mass and Hypertrophy by Echocardiography and Cardiac Magnetic Resonance: The Multi-Ethnic Study of Atherosclerosis
Anderson C. Armstrong et al.
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES (2014)
Right heart dysfunction in heart failure with preserved ejection fraction
Vojtech Melenovsky et al.
EUROPEAN HEART JOURNAL (2014)
PDE5 inhibitor efficacy is estrogen dependent in female heart disease
Hideyuki Sasaki et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
Cardiovascular Phenotype in HFpEF Patients With or Without Diabetes A RELAX Trial Ancillary Study
Brian R. Lindman et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2014)
A heart-adipose tissue connection in the regulation of energy metabolism
Sheila Collins
NATURE REVIEWS ENDOCRINOLOGY (2014)
Spironolactone for Heart Failure with Preserved Ejection Fraction
Bertram Pitt et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Angiotensin-Neprilysin Inhibition versus Enalapril in Heart Failure
John J. V. McMurray et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Circulating Levels of Tumor Necrosis Factor-Alpha Receptor 2 Are Increased in Heart Failure with Preserved Ejection Fraction Relative to Heart Failure with Reduced Ejection Fraction: Evidence for a Divergence in Pathophysiology
Brendan N. Putko et al.
PLOS ONE (2014)
Obesity, metabolic dysfunction, and cardiac fibrosis: pathophysiological pathways, molecular mechanisms, and therapeutic opportunities
Michele Cavalera et al.
TRANSLATIONAL RESEARCH (2014)
Ketone bodies as signaling metabolites
John C. Newman et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2014)
Randomized double-blind placebocontrolled trial of perhexiline in heart failure with preserved ejection fraction syndrome
Satnam Singh et al.
FUTURE CARDIOLOGY (2014)
Preconditioning with soluble guanylate cyclase activation prevents postischemic inflammation and reduces nitrate tolerance in heme oxygenase-1 knockout mice
Walter Z. Wang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2013)
Targeting mitochondrial oxidative metabolism as an approach to treat heart failure
Natasha Fillmore et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)
Mitochondrial Complex I Deficiency Increases Protein Acetylation and Accelerates Heart Failure
Georgios Karamanlidis et al.
CELL METABOLISM (2013)
Protein Kinase G Positively Regulates Proteasome-Mediated Degradation of Misfolded Proteins
Mark J. Ranek et al.
CIRCULATION (2013)
Cardiac Metabolism in Heart Failure Implications Beyond ATP Production
Torsten Doenst et al.
CIRCULATION RESEARCH (2013)
Mechanisms of Altered Ca2+ Handling in Heart Failure
Min Luo et al.
CIRCULATION RESEARCH (2013)
Plasma Free Fatty Acids and Risk of Heart Failure The Cardiovascular Health Study
Luc Djousse et al.
CIRCULATION-HEART FAILURE (2013)
Myocardial Titin Hypophosphorylation Importantly Contributes to Heart Failure With Preserved Ejection Fraction in a Rat Metabolic Risk Model
Nazha Hamdani et al.
CIRCULATION-HEART FAILURE (2013)
Effects of carvedilol on heart failure with preserved ejection fraction: the Japanese Diastolic Heart Failure Study (J-DHF)
Kazuhiro Yamamoto et al.
EUROPEAN JOURNAL OF HEART FAILURE (2013)
Galectin-3 in heart failure with preserved ejection fraction
Rudolf A. de Boer et al.
EUROPEAN JOURNAL OF HEART FAILURE (2013)
Increased cGMP promotes healthy expansion and browning of white adipose tissue
Michaela M. Mitschke et al.
FASEB JOURNAL (2013)
Effect of Phosphodiesterase-5 Inhibition on Exercise Capacity and Clinical Status in Heart Failure With Preserved Ejection Fraction A Randomized Clinical Trial
Margaret M. Redfield et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2013)
Metabolic effects of glutamine on the heart: Anaplerosis versus the hexosamine biosynthetic pathway
Benjamin Lauzier et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2013)
Molecular determinants for cardiovascular TRPC6 channel regulation by Ca2+/calmodulin-dependent kinase II
Juan Shi et al.
JOURNAL OF PHYSIOLOGY-LONDON (2013)
A Novel Paradigm for Heart Failure With Preserved Ejection Fraction Comorbidities Drive Myocardial Dysfunction and Remodeling Through Coronary Microvascular Endothelial Inflammation
Walter J. Paulus et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2013)
Impaired Aerobic Capacity and Physical Functional Performance in Older Heart Failure Patients With Preserved Ejection Fraction: Role of Lean Body Mass
Mark J. Haykowsky et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2013)
Biomarkers in acutely decompensated heart failure with preserved or reduced ejection fraction
Kalkidan Bishu et al.
AMERICAN HEART JOURNAL (2012)
Low Myocardial Protein Kinase G Activity in Heart Failure With Preserved Ejection Fraction
Loek van Heerebeek et al.
CIRCULATION (2012)
A TRPC6-Dependent Pathway for Myofibroblast Transdifferentiation and Wound Healing In Vivo
Jennifer Davis et al.
DEVELOPMENTAL CELL (2012)
Collagen Cross-Linking But Not Collagen Amount Associates With Elevated Filling Pressures in Hypertensive Patients With Stage C Heart Failure Potential Role of Lysyl Oxidase
Begona Lopez et al.
HYPERTENSION (2012)
Increased Proximal Arterial Stiffness and Cardiac Response With Moderate Exercise in Patients With Heart Failure and Preserved Ejection Fraction
Lamia Tartiere-Kesri et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2012)
CaMKII determines mitochondrial stress responses in heart
Mei-ling A. Joiner et al.
NATURE (2012)
Prevalence and Significance of Alterations in Cardiac Structure and Function in Patients With Heart Failure and a Preserved Ejection Fraction
Michael R. Zile et al.
CIRCULATION (2011)
Deletion of Cardiomyocyte Mineralocorticoid Receptor Ameliorates Adverse Remodeling After Myocardial Infarction
Daniela Fraccarollo et al.
CIRCULATION (2011)
Cardiac Inflammation Contributes to Changes in the Extracellular Matrix in Patients With Heart Failure and Normal Ejection Fraction
Dirk Westermann et al.
CIRCULATION-HEART FAILURE (2011)
HDAC3-dependent Reversible Lysine Acetylation of Cardiac Myosin Heavy Chain Isoforms Modulates Their Enzymatic and Motor Activity
Sadhana A. Samant et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Decreased Cardiac Functional Reserve in Heart Failure With Preserved Systolic Function
Holly S. Norman et al.
JOURNAL OF CARDIAC FAILURE (2011)
High-carbohydrate High-fat Diet-induced Metabolic Syndrome and Cardiovascular Remodeling in Rats
Sunil K. Panchal et al.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2011)
CaMKII in myocardial hypertrophy and heart failure
Mark E. Anderson et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2011)
Diastolic Tissue Doppler Indexes Correlate With the Degree of Collagen Expression and Cross-Linking in Heart Failure and Normal Ejection Fraction
Mario Kasner et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2011)
Early development of intracellular calcium cycling defects in intact hearts of spontaneously hypertensive rats
Sunil Kapur et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2010)
Inhibition of TRPC6 Channel Activity Contributes to the Antihypertrophic Effects of Natriuretic Peptides-Guanylyl Cyclase-A Signaling in the Heart
Hideyuki Kinoshita et al.
CIRCULATION RESEARCH (2010)
Impaired Heart Rate Recovery and Chronotropic Incompetence in Patients With Heart Failure With Preserved Ejection Fraction
Thanh Trung Phan et al.
CIRCULATION-HEART FAILURE (2010)
Analysis of Metabolic Remodeling in Compensated Left Ventricular Hypertrophy and Heart Failure
Takao Kato et al.
CIRCULATION-HEART FAILURE (2010)
Filling Pressures and Collagen Metabolism in Hypertensive Patients With Heart Failure and Normal Ejection Fraction
Arantxa Gonzalez et al.
HYPERTENSION (2010)
Exogenous NAD Blocks Cardiac Hypertrophic Response via Activation of the SIRT3-LKB1-AMP-activated Kinase Pathway
Vinodkumar B. Pillai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation Novel mechanism of cardiac stress modulation by PDE5 inhibition
Norimichi Koitabashi et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2010)
Global Cardiovascular Reserve Dysfunction in Heart Failure With Preserved Ejection Fraction
Barry A. Borlaug et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2010)
Myocardial Fatty Acid Metabolism in Health and Disease
Gary D. Lopaschuk et al.
PHYSIOLOGICAL REVIEWS (2010)
cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action
Sharron H. Francis et al.
PHARMACOLOGICAL REVIEWS (2010)
Protein Kinase G Modulates Human Myocardial Passive Stiffness by Phosphorylation of the Titin Springs
Martina Krueger et al.
CIRCULATION RESEARCH (2009)
Characterization of the inflammatory and fibrotic response in a mouse model of cardiac pressure overload
Ying Xia et al.
HISTOCHEMISTRY AND CELL BIOLOGY (2009)
Diabetes mellitus accelerates left ventricular diastolic dysfunction through activation of the renin-angiotensin system in hypertensive rats
Shigefumi Fukui et al.
HYPERTENSION RESEARCH (2009)
Contractility and Ventricular Systolic Stiffening in Hypertensive Heart Disease Insights Into the Pathogenesis of Heart Failure With Preserved Ejection Fraction
Barry A. Borlaug et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2009)
Heart Failure With Preserved Ejection Fraction Is Characterized by Dynamic Impairment of Active Relaxation and Contraction of the Left Ventricle on Exercise and Associated With Myocardial Energy Deficiency
Thanh T. Phan et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2009)
Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction A Community-Based Study
Carolyn S. P. Lam et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2009)
Cyclic GMP Kinase and RhoA Ser188 Phosphorylation Integrate Pro- and Antifibrotic Signals in Blood Vessels
Naoki Sawada et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
A redox-dependent pathway for regulating class IIHDACs and cardiac hypertrophy
Tetsuro Ago et al.
CELL (2008)
Regulator of G-protein signaling subtype 4 mediates antihypertrophic effect of locally secreted natriuretic peptides in the heart
Takeshi Tokudome et al.
CIRCULATION (2008)
Diastolic stiffness of the failing diabetic heart - Importance of fibrosis, advanced glycation end products, and myocyte resting tension
Loek van Heerebeek et al.
CIRCULATION (2008)
Hypertension-induced remodeling of cardiac excitation-contraction coupling in ventricular myocytes occurs prior to hypertrophy development
Ye Chen-Izu et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2007)
Control of in vivo contraction/relaxation kinetics by myosin binding protein C: Protein kinase A phosphorylation-dependent and -independent regulation
Takahiro Nagayama et al.
CIRCULATION (2007)
Impact of arterial load and loading sequence on left ventricular tissue velocities in humans
Barry A. Borlaug et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2007)
Role of oxidative stress in cardiac hypertrophy and remodeling
Eiki Takimoto et al.
HYPERTENSION (2007)
Therapeutic effects of angiotensin II type 1 receptor blocker at an advanced stage of hypertensive diastolic heart failure
Mayu Nishio et al.
JOURNAL OF HYPERTENSION (2007)
Cardiovascular features of heart failure with preserved ejection fraction versus nonfailing hypertensive left ventricular hypertrophy in the urban Baltimore community - The role of atrial remodeling/dysfunction
Vojtech Melenovsky et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2007)
TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling
Koichiro Kuwahara et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Impaired chronotropic and vasodilator reserves limit exercise capacity in patients with heart failure and a preserved ejection fraction
Barry A. Borlaug et al.
CIRCULATION (2006)
Trends in prevalence and outcome of heart failure with preserved ejection fraction
Theophilus E. Owan et al.
NEW ENGLAND JOURNAL OF MEDICINE (2006)
Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy
Yongli Kong et al.
CIRCULATION (2006)
Myocardial structure and function differ in systolic and diastolic heart failure
L van Heerebeek et al.
CIRCULATION (2006)
Selective loss of fine tuning of Gq/11 signaling by RGS2 protein exacerbates cardiomyocyte hypertrophy
W Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Beneficial effect of candesartan on rat diastolic heart failure
R Wake et al.
JOURNAL OF PHARMACOLOGICAL SCIENCES (2005)
Dynamics of flow velocities in endocardial and epicardial coronary arterioles
E Toyota et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2005)
Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle
Z Arany et al.
CELL METABOLISM (2005)
Ventricular structure and function in aged dogs with renal hypertension - A model of experimental diastolic heart failure
VK Munagala et al.
CIRCULATION (2005)
Is plasma cardiotrophin-1 a marker of hypertensive heart disease?
B López et al.
JOURNAL OF HYPERTENSION (2005)
Cardiomyocyte stiffness in Diastolic heart failure
A Borbély et al.
CIRCULATION (2005)
Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy
E Takimoto et al.
NATURE MEDICINE (2005)
Paradoxical downregulation of the glucose oxidation pathway despite enhanced flux in severe heart failure
B Lei et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2004)
AT1 receptor blocker added to ACE inhibitor provides benefits at advanced stage of hypertensive diastolic heart failure
J Yoshida et al.
HYPERTENSION (2004)
Combined ventricular systolic and arterial stiffening in patients with heart failure and preserved ejection fraction - Implications for systolic and diastolic reserve limitations
M Kawaguchi et al.
CIRCULATION (2003)
Absolute concentrations of high-energy phosphate metabolites in normal, hypertrophied, and failing human myocardium measured noninvasively with 31P-SLOOP magnetic resonance spectroscopy
M Beer et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2002)
Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy
CL Zhang et al.
CELL (2002)
Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy
VG Dávila-Román et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2002)
Role of cyclic GMP-denendent protein kinase in the contractile response to exogenous nitric oxide in rat cardiac myocytes
J Layland et al.
JOURNAL OF PHYSIOLOGY-LONDON (2002)
Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Gαq/Gα11 in cardiomyocytes
N Wettschureck et al.
NATURE MEDICINE (2001)
cGMP-dependent protein kinase phosphorylates and inactivates RhoA
N Sawada et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)
Physiology of nitric oxide in skeletal muscle
JS Stamler et al.
PHYSIOLOGICAL REVIEWS (2001)
Time-course changes in left ventricular geometry and function during the development of hypertension in Dahl salt-sensitive rats
P Qu et al.
HYPERTENSION RESEARCH (2000)
Roles of renin-angiotensin and endothelin systems in development of diastolic heart failure in hypertensive hearts
K Yamamoto et al.
CARDIOVASCULAR RESEARCH (2000)
nNOS and eNOS modulate cGMP formation and vascular response in contracting fast-twitch skeletal muscle
KS Lau et al.
PHYSIOLOGICAL GENOMICS (2000)
Renal function and structure in diabetic, hypertensive, obese ZDFxSHHF-hybrid rats
SP Tofovic et al.
RENAL FAILURE (2000)
Development of different phenotypes of hypertensive heart failure: systolic versus diastolic failure in Dahl salt-sensitive rats
R Doi et al.
JOURNAL OF HYPERTENSION (2000)