Journal
DNA AND CELL BIOLOGY
Volume 35, Issue 11, Pages 722-729Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/dna.2016.3422
Keywords
lncRNA; HOXC-AS1; Ox-LDL; cholesterol; HOXC6
Funding
- National Natural Sciences Foundation of China [81472009, 81500387]
- Natural Science Fund of Guangdong [2014A030313287, 2014A030310135, 2015A030313245]
- Medical Scientific Research Foundation of Guangdong Province [B2014245]
- President Foundation of Nanfang Hospital, Southern Medical University [2012B002, 2013B004, 2014Z003]
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Atherosclerosis is a common pathological basis of cardiovascular disease, which remains the leading cause of mortality. Long noncoding RNAs (lncRNAs) are newly studied non-protein-coding RNAs involved in gene regulation, but how lncRNAs exert regulatory effect on atherosclerosis remains unclear. In this study, we found that lncRNA HOXC cluster antisense RNA 1 (HOXC-AS1) and homeobox C6 (HOXC6) were downregulated in carotid atherosclerosis by performing microarray analysis. The results were verified in atherosclerotic plaques and normal arterial intima tissues by quantitative reverse transcription PCR and western blot analysis. Lentivirus-mediated overexpression of HOXC-AS1 induced HOXC6 expression at mRNA and protein levels in THP-1 macrophages. Besides, oxidized low-density lipoprotein (Ox-LDL) decreased expression of HOXC-AS1 and HOXC6 in a time-dependent manner. Induction of cholesterol accumulation by Ox-LDL could be partly suppressed by overexpression of HOXC-AS1.
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