Journal
NATURE NEUROSCIENCE
Volume 24, Issue 1, Pages 105-115Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41593-020-00747-8
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Funding
- National Cancer Institute cancer center support grant [P30 CA060553]
- National Institutes of Health (NIH) [1S10OD010398-01]
- NIH National Eye Institute [F31 EY029593, T32 EY025202]
- NIH Director's New Innovator (DP2) award [EY026770]
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A systematic spatial offset between ON and OFF receptive subfields in F-mini-ON retinal ganglion cells was discovered, originating from a network of electrical synapses instead of dendritic positions. The asymmetry in morphology and connectivity of these RGCs explains their receptive field offset, affecting the precision of edge-location representation. This RGC network forms a new electrical channel combining the ON and OFF feedforward pathways within the output layer of the retina.
In the vertebrate retina, the location of a neuron's receptive field in visual space closely corresponds to the physical location of synaptic input onto its dendrites, a relationship called the retinotopic map. We report the discovery of a systematic spatial offset between the ON and OFF receptive subfields in F-mini-ON retinal ganglion cells (RGCs). Surprisingly, this property does not come from spatially offset ON and OFF layer dendrites, but instead arises from a network of electrical synapses via gap junctions to RGCs of a different type, the F-mini-OFF. We show that the asymmetric morphology and connectivity of these RGCs can explain their receptive field offset, and we use a multicell model to explore the effects of receptive field offset on the precision of edge-location representation in a population. This RGC network forms a new electrical channel combining the ON and OFF feedforward pathways within the output layer of the retina.
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