Journal
NATURE METHODS
Volume 18, Issue 1, Pages 23-25Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41592-020-01040-z
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Funding
- Allen Institute for Brain Science [U19MH114830]
- National Institute of Mental Health
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Spatially resolved transcriptomics has great potential in unraveling the organization of brain cell types and their relationship with connectivity, circuit dynamics, behavior, and disease, but technical challenges need to be overcome to fully realize its potentials.
One major challenge in neuroscience is to gain a systematic understanding of the extraordinary diversity of brain cell types and how they contribute to brain function. Spatially resolved transcriptomics holds unmatched promise in unraveling the organization of brain cell types and their relationship with connectivity, circuit dynamics, behavior and disease. Here we discuss neuroscience applications of various spatially resolved transcriptomics methods, as well as technical challenges that need to be overcome to realize their full potentials.
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