The distribution of cellular turnover in the human body

We integrated ubiquity, mass and lifespan of all major cell types to achieve a comprehensive quantitative description of cellular turnover. We found a total cellular mass turnover of 80 +/- 20 grams per day, dominated by blood cells and gut epithelial cells. In terms of cell numbers, close to 90% of the (0.33 +/- 0.02) x 10(12) cells per day turnover was blood cells. A comprehensive census of the dynamics of death and regeneration of cells and tissues provides an estimation of the distribution of cellular turnover in the human body.

Automated summary

The research integrated ubiquity, mass, and lifespan of major cell types to quantitatively describe cellular turnover, finding a total cellular mass turnover of 80+/-20 grams per day, primarily from blood cells and gut epithelial cells. The study also revealed that close to 90% of the daily cell turnover was from blood cells, providing an estimation of the distribution of cellular turnover in the human body.