Journal
NATURE GENETICS
Volume 53, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41588-020-00741-7
Keywords
-
Categories
Funding
- National Institute of Dental and Craniofacial Research [U01-DE020078, R01-DE016148, R01-DE027023, U01-DE024430]
- National Human Genome Research Institute [X01-HG007821, X01-HG007485]
- University of Washington from the National Institute for Dental and Craniofacial Research [HHSN268201200008I]
- Procter & Gamble, Company [UCRI-2015-1117-HN-532]
- Center for Human Evolution and Development at Penn State
- Science Foundation of Ireland Walton Fellowship [04.W4/B643]
- US National Institute of Justice [2008-DN-BX-K125, 2018-DU-BX-0219]
- US Department of Defense
- National Institute of Justice [2018-DU-BX-0219, 2015-R2-CX-0023, 2014-DN-BX-K031]
- Wellcome [102215/2/13/2]
- Research Fund KU Leuven [BOF-C1, C14/15/081, C14/20/081]
- Research Program of the Research Foundation-Flanders (FWO) [G078518N]
- Howard Hughes Medical Institute
- March of Dimes Foundation [1-FY15-312]
- UK Medical Research Council [102215/2/13/2]
- Research Foundation-Flanders [G078714N]
- MRC [MC_PC_19009] Funding Source: UKRI
Ask authors/readers for more resources
A multivariate genome-wide association study identifies 203 signals associated with facial variation, enriched for enhancer activity in cranial neural crest cells and craniofacial tissues. Multiple regions carry multiple signals, suggesting potential coordinated genetic actions.
The human face is complex and multipartite, and characterization of its genetic architecture remains challenging. Using a multivariate genome-wide association study meta-analysis of 8,246 European individuals, we identified 203 genome-wide-significant signals (120 also study-wide significant) associated with normal-range facial variation. Follow-up analyses indicate that the regions surrounding these signals are enriched for enhancer activity in cranial neural crest cells and craniofacial tissues, several regions harbor multiple signals with associations to different facial phenotypes, and there is evidence for potential coordinated actions of variants. In summary, our analyses provide insights into the understanding of how complex morphological traits are shaped by both individual and coordinated genetic actions. A multivariate genome-wide association study identifies 203 signals associated with facial variation. These signals are enriched for enhancer activity in cranial neural crest cells and craniofacial tissues.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available