4.8 Article

Cholesterol access in cellular membranes controls Hedgehog signaling

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Sphingolipids controlling ciliary and microvillar function

Fabian Kaiser et al.

FEBS LETTERS (2020)

Article Biochemistry & Molecular Biology

Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2

Hongwu Qian et al.

Article Biochemistry & Molecular Biology

Molecular Discrimination between Two Conformations of Sphingomyelin in Plasma Membranes

Shreya Endapally et al.

Article Multidisciplinary Sciences

Motional dynamics of single Patched1 molecules in cilia are controlled by Hedgehog and cholesterol

Lucien E. Weiss et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Developmental Biology

Biochemical mechanisms of vertebrate hedgehog signaling

Jennifer H. Kong et al.

DEVELOPMENT (2019)

Review Cell Biology

Establishing and regulating the composition of cilia for signal transduction

Maxence Nachury et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Article Multidisciplinary Sciences

Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi

Xiaofeng Qi et al.

NATURE (2019)

Article Multidisciplinary Sciences

Smoothened stimulation by membrane sterols drives Hedgehog pathway activity

Ishan Deshpande et al.

NATURE (2019)

Article Biochemistry & Molecular Biology

Structures of vertebrate Patched and Smoothened reveal intimate links between cholesterol and Hedgehog signalling

Christiane Kowatsch et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2019)

Article Biochemistry & Molecular Biology

The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism

Amalie F. Rudolf et al.

NATURE CHEMICAL BIOLOGY (2019)

Article Multidisciplinary Sciences

Structural basis of sterol recognition by human hedgehog receptor PTCH1

Chao Qi et al.

SCIENCE ADVANCES (2019)

Article Biochemistry & Molecular Biology

Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins

Mikael B. L. Winkler et al.

Article Multidisciplinary Sciences

Structural basis for the recognition of Sonic Hedgehog by human Patchedl

Xin Gong et al.

SCIENCE (2018)

Correction Biochemistry & Molecular Biology

Structural Basis of Smoothened Activation in Hedgehog Signaling (vol 174, pg 312, 2018)

Pengxiang Huang et al.

Article Multidisciplinary Sciences

Structures of human Patched and its complex with native palmitoylated sonic hedgehog

Xiaofeng Qi et al.

NATURE (2018)

Article Multidisciplinary Sciences

Macrophages release plasma membrane-derived particles rich in accessible cholesterol

Cuiwen He et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Biochemistry & Molecular Biology

Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched

Yunxiao Zhang et al.

Article Biochemistry & Molecular Biology

Cilia-Associated Oxysterols Activate Smoothened

David R. Raleigh et al.

MOLECULAR CELL (2018)

Article Biochemistry & Molecular Biology

Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol

Shu-Lin Liu et al.

NATURE CHEMICAL BIOLOGY (2017)

Article Biochemistry & Molecular Biology

Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling

Xu Xiao et al.

MOLECULAR CELL (2017)

Article Multidisciplinary Sciences

Rapid, direct activity assays for Smoothened reveal Hedgehog pathway regulation by membrane cholesterol and extracellular sodium

Benjamin R. Myers et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Biochemistry & Molecular Biology

An Actin Network Dispatches Ciliary GPCRs into Extracellular Vesicles to Modulate Signaling

Andrew R. Nager et al.

Article Biochemistry & Molecular Biology

Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision

Siew Cheng Phua et al.

Article Biochemistry & Molecular Biology

Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome

Robert Blassberg et al.

HUMAN MOLECULAR GENETICS (2016)

Article Biochemistry & Molecular Biology

Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling

Pengxiang Huang et al.

Article Multidisciplinary Sciences

Structural basis of Smoothened regulation by its extracellular domains

Eamon F. X. Byrne et al.

NATURE (2016)

Article Multidisciplinary Sciences

Structure of human Niemann-Pick C1 protein

Xiaochun Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Review Biochemistry & Molecular Biology

A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins

Joseph L. Goldstein et al.

Article Biochemistry & Molecular Biology

Regulation of the oncoprotein Smoothened by small molecules

Hayley J. Sharpe et al.

NATURE CHEMICAL BIOLOGY (2015)

Article Biology

Flagellar membranes are rich in raft-forming phospholipids

Mauro Serricchio et al.

BIOLOGY OPEN (2015)

Article Multidisciplinary Sciences

Structure of the human smoothened receptor bound to an antitumour agent

Chong Wang et al.

NATURE (2013)

Article Biochemistry & Molecular Biology

Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling

Daniel Nedelcu et al.

NATURE CHEMICAL BIOLOGY (2013)

Article Multidisciplinary Sciences

Use of mutant 125I-Perfringolysin O to probe transport and organization of cholesterol in membranes of animal cells

Akash Das et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Biochemistry & Molecular Biology

Oxysterols are allosteric activators of the oncoprotein Smoothened

Sigrid Nachtergaele et al.

NATURE CHEMICAL BIOLOGY (2012)

Article Biochemical Research Methods

CAVER 3.0: A Tool for the Analysis of Transport Pathways in Dynamic Protein Structures

Eva Chovancova et al.

PLOS COMPUTATIONAL BIOLOGY (2012)

Article Multidisciplinary Sciences

The Hedgehog Receptor Patched Is Involved in Cholesterol Transport

Michel Bidet et al.

PLOS ONE (2011)

Article Biochemistry & Molecular Biology

Cholesterol Exposure at the Membrane Surface Is Necessary and Sufficient to Trigger Perfringolysin O Binding

John J. Flanagan et al.

BIOCHEMISTRY (2009)

Letter Biochemistry & Molecular Biology

Structural Ties between Cholesterol Transport and Morphogen Signaling

J. Fernando Bazan et al.

Article Cell Biology

Flagellar membrane localization via association with lipid rafts

Kevin M. Tyler et al.

JOURNAL OF CELL SCIENCE (2009)

Article Multidisciplinary Sciences

Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma

Robert L. Yauch et al.

SCIENCE (2009)

Editorial Material Biochemistry & Molecular Biology

The Hedgehog Signaling Pathway: Where Did It Come From?

George Hausmann et al.

PLOS BIOLOGY (2009)

Article Multidisciplinary Sciences

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

Rodney E. Infante et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

Purified NPC1 protein - I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein

Rodney E. Infante et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Purified NPC1 protein - II. Localization of sterol binding to a 240-amino acid soluble luminal loop

Rodney E. Infante et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Multidisciplinary Sciences

Patched1 regulates Hedgehog signaling at the primary cilium

Rajat Rohatgi et al.

SCIENCE (2007)

Article Biochemistry & Molecular Biology

Oxysterols pathway in are novel activators of the hedgehog pluripotent mesenchymal cells

Jennifer R. Dwyer et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Multidisciplinary Sciences

Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells

Ryan B. Corcoran et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Multidisciplinary Sciences

Theory of the deuterium NMR of sterol-phospholipid membranes

H McConnell et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Multidisciplinary Sciences

Vertebrate Smoothened functions at the primary cilium

KC Corbit et al.

NATURE (2005)

Article Multidisciplinary Sciences

Condensed complexes in vesicles containing cholesterol and phospholipids

A Radhakrishnan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Cholesterol oxidase senses subtle changes in lipid bilayer structure

KW Ahn et al.

BIOCHEMISTRY (2004)

Article Multidisciplinary Sciences

How cholesterol homeostasis is regulated by plasma membrane cholesterol in excess of phospholipids

Y Lange et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Multidisciplinary Sciences

Hedgehog signalling in the mouse requires intraflagellar transport proteins

DW Huangfu et al.

NATURE (2003)

Article Genetics & Heredity

A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis

MK Cooper et al.

NATURE GENETICS (2003)

Review Biochemistry & Molecular Biology

Condensed complexes of cholesterol and phospholipids

HM McConnell et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2003)

Article Chemistry, Physical

Saturated phospholipids with high melting temperatures form complexes with cholesterol in monolayers

SL Keller et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2000)

Article Biochemistry & Molecular Biology

Chemical activity of cholesterol in membranes

A Radhakrishnan et al.

BIOCHEMISTRY (2000)

Article Biochemistry & Molecular Biology

Efflux of cholesterol from different cellular pools

MP Haynes et al.

BIOCHEMISTRY (2000)