4.8 Article

Ribosomopathy-associated mutations cause proteotoxic stress that is alleviated by TOR inhibition

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Article Cell Biology

Ribosomopathy-associated mutations cause proteotoxic stress that is alleviated by TOR inhibition

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Summary: Ribosomes are essential molecular machines for protein synthesis, and deficiencies in ribosomal proteins can lead to proteotoxic stress and cell apoptosis. Modulating the integrated stress response and autophagy can affect the severity of ribosomal protein deficiency-induced harm, suggesting potential cytoprotective strategies for ribosomopathies.

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