Structure elucidation of a novel cyclic tripeptide from the marine-derived fungus Aspergillus ochraceopetaliformis DSW-2

A novel cyclic tripeptide, sclerotiotide M (1), was isolated from the culture of a marine derived fungus Aspergillus ochraceopetaliformis DSW-2, together with four known compounds (2-5). The planar structure of 1 was established by 1 D and 2 D NMR data, supported by mass spectrometry, and the relative configuration was established by calculated NMR chemical shifts coupled with a statistical method (DP4+). All the compounds (1-5) displayed weak cytotoxic activities against cancer cell lines HPAC and BXPC3, with IC50 values over 20 mu M.

Automated summary

A novel cyclic tripeptide, sclerotiotide M (1), was isolated from the culture of marine derived fungus Aspergillus ochraceopetaliformis DSW-2, along with four known compounds. The structure of sclerotiotide M (1) was determined through various analytical methods, and it, along with the other compounds, exhibited weak cytotoxic activities against cancer cell lines HPAC and BXPC3.