Journal
NATURAL PRODUCT RESEARCH
Volume 36, Issue 5, Pages 1327-1331Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2020.1862832
Keywords
Toxicity; PBMCs; time-kill; MIC; methyl salicylate; microorganism; mycobacterium
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Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS)
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This study is the first to relate cytogenotoxicity with oxidative metabolism and antimicrobial activity of Gaultheria procumbens essential oil. The results showed that the essential oil has promising potential for developing future formulations to treat infections caused by microorganisms, as it exhibited effective inhibition and killing of various microorganisms.
This study investigated the chemical constituents of Gaultheria procumbens essential oil and is the first to relate cytogenotoxicity with oxidative metabolism and antimicrobial activity. Chromatographic analysis of the essential oil showed methyl salicylate (99.96%) and linalool (0.04%) as the major compounds. The essential oil showed no signs of cytogenotoxicity at different concentrations (1.82 to 58.34 mg mL(-1)). Furthermore, G. procumbens essential oil and methyl salicylate were used to evaluate the minimal inhibitory concentrations (MIC) and minimal microbicidal concentrations (MMC). The results showed efficacy against several microorganisms, including Aeromonas caviae, Candida albicans, and Mycobacterium fortuitum with MIC values ranging from 1.82 to 3.64 mg mL(-1) and MMC values ranging from 3.64 to 12.67 mg mL(-1), which were confirmed by time-kill kinetics. Based on our results, the essential oil is a promising alternative to developing future formulations to treat infections caused by microorganisms.
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