Journal
NATURAL PRODUCT RESEARCH
Volume 36, Issue 13, Pages 3262-3270Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2020.1853725
Keywords
Penicillium vulpinum; andrastins; endophytic fungus; antibacterial activities
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Funding
- National Natural Science Foundation of China [21762007]
- Guangxi Natural Science Foundation of China [2018GXNSFAA281169]
- Project of State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University) [CMEMR2016A06, CMEMR2018-C29]
- Guangxi Scholarship Fund of Guangxi Education Department
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Three new andrastin derivatives were isolated from an endophytic fungus, Penicillium vulpinum, along with four known analogues. Their structures were determined by NMR, and the absolute configurations were further confirmed using experimental and calculated ECD spectra. Compound 5 exhibited significant antibacterial activity against Bacillus paratyphosus B, while compounds 2 and 6 showed remarkable inhibitory activities against Bacillus megaterium.
Three new andrastin derivatives, 10-formyl andrastone A (1), 10-demethylated andrastone A (2) and andrastin G (3), together with four known andrastin analogues (4-7) were isolated from an endophytic fungus Penicillium vulpinum. Their structures were determined by 1 D, 2 D NMR, and the absolute configurations were further determined by experimental and calculated ECD spectra. Compound 5 exhibited significant antibacterial activity against Bacillus paratyphosus B with an MIC value of 6.25 mu g center dot mL(-1). Compounds 2 and 6 showed remarkable inhibitory activities against Bacillus megaterium with the MIC value of 6.25 mu g center dot mL(-1), respectively.
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