A new squalene derivative from Physalis angulata L. (Solanaceae)

Physalis angulata is an annual herb which has tremendous medicinal uses. The antioxidant activity of the whole plant extract of Physalis angulata was investigated using DPPH radical scavenging activity. Purified compounds were isolated using column chromatography method. Their structures were determined using various spectroscopic techniques. A new compound named as Squalen-1-ol, Phytol, squalene and alpha-tocopherol were isolated. These compounds were isolated for the first time from Physalis angulata. The extract of Physalis angulata gave a significant IC50 value of 0.77 mg/mL as compared with the standard ascorbic acid with IC50 value of 0.24 mg/mL. It can be correlated that the antioxidant activity of Physalis angulata could be attributed to the presence of alpha - tocopherol which is a known antioxidant. The presence of these compounds gives a further added pharmacological value to the plant.

Automated summary

Physalis angulata is a medicinal herb with significant antioxidant activity. Various compounds, including a new compound named Squalen-1-ol, Phytol, squalene, and alpha-tocopherol, were isolated from the plant. These compounds contribute to the pharmacological value of Physalis angulata.