Journal
NATURAL PRODUCT RESEARCH
Volume 36, Issue 4, Pages 1100-1104Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2020.1851220
Keywords
Sambucus nigra L; flavonoids; cytotoxic activity; bladder cancer; polymeric micelles; Pluronic (R) F127
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Funding
- Coordenadoria de Aperfeicoamento Pessoal de Nivel Superior (CAPES)
- Laboratorio de Fitotecnologia and Laboratorio de Pesquisas Clinicas da Universidade Federal de Ouro Preto, Minas Gerais
- Laboratorio de Fitoquimica da Faculdade de Farmacia da Universidade Federal de Minas Gerais, Brazil
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This study evaluated the cytotoxic activity of Sambucus nigra L. flower extracts on bladder carcinoma cells and human fibroblast cells. The results showed that flavonoids may be responsible for the cytotoxic activity in bladder carcinoma cells, and micellar solutions can enhance the effect of the butanolic fraction.
Bladder cancer has a high incidence and recurrence rate among patients worldwide. This study aimed to evaluate the cytotoxic activity of fractions of Sambucus nigra L. flower extracts on bladder carcinoma cells (T24 cells) and human fibroblast cells (MRC-5). The butanolic fraction (F-BuOH) was characterized by UPLC-DAD-MS/MS and nine flavonoids were identified. Rutin was the major compound. The cytotoxic activity of this fraction was observed in the T24 cells but not in MRC-5 cells, indicating selectivity. F-BuOH was incorporated in micellar solutions of Pluronic (R) F127 and cytotoxic effect for T24 cells was observed again. In vitro assay demonstrated a controlled release of the fraction from the micelles. The results obtained showed that flavonoids are the possible responsible for cytotoxic activity in bladder carcinoma cells. In addition, micellar solutions act together to increase the action of the butanolic fraction. [GRAPHICS]
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