4.4 Article

The effect of emodin on melanogenesis through the modulation of ERK and MITF signaling pathway

Journal

NATURAL PRODUCT RESEARCH
Volume 36, Issue 4, Pages 1084-1088

Publisher

TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2020.1849200

Keywords

Emodin; melanogenesis; MITF; ERK; SIRT1

Funding

  1. National Research Foundation of Korea (NRF)
  2. Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [2017R1D1A3B06028000]
  3. National Research Foundation of Korea [2017R1D1A3B06028000] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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This study found that emodin derived from Polygonum multiflorum can promote melanin production in B16F1 cells by increasing the expression levels of tyrosinase, tyrosine related protein, MITF, and SIRT1 proteins. These findings suggest that emodin may have the potential to prevent graying of hair.
The aim of this study was to investigate the effect of emodin derived from Polygonum multiflorum on melanin production in B16F1 cells. In this study, emodin did not show antioxidant activity in DPPH radical and reducing power assays. However, it was found that emodin scavenged intracellular H2O2. Emodin increased not only tyrosinase activity but also melanin synthesis in vitro. Moreover, emodin enhanced melanin synthesis by increasing the expression level of tyrosinase (TYR), tyrosine related protein (TRP)-1, TRP-2, MITF and SIRT1 proteins in live cells treated with H2O2 compared with H2O2 treatment group in the analyses of western blot and immunofluorescence. Moreover, emodin suppressed ERK activation by SIRT1 and FOXO1. Thus, emodin promoted melanin synthesis by increasing the expression of TRP-1, TRP-2, tyrosinase through the activation of MITF transcription factor. These findings suggest that emodin could promote melanin production related to anti-hair graying.

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