Journal
NATURAL PRODUCT RESEARCH
Volume 36, Issue 14, Pages 3603-3609Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2021.1872568
Keywords
Chaetomium globosum; secondary metabolites; cytochalasan
Categories
Funding
- Open Fund from Hubei Engineering Research Center for Protection and Utilization of Special Biological Resources in the Hanjiang River Basin [2019-03]
- Hubei Provincial Outstanding Young and Middle-Aged Science and Technology Innovation Team Project [T201813]
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Two novel cytochalasans, armochaetoglasin J and armochaetoglasin K, were isolated from Chaetomium globosum along with 14 known analogues. Their structures were elucidated using various techniques, but both armochaetoglasins J and K were found to be inactive against several cancer cell lines.
Two novel cytochalasans, armochaetoglasin J (1) and armochaetoglasin K (2), along with 14 known analogues (3-16) were isolated from Chaetomium globosum. Their structures were elucidated by HRESIMS, NMR spectroscopy, single-crystal X-ray crystallography, and ECD spectra. Armochaetoglasins J and K were found to be inactive against the HepG2, HT-29, K562, HL-60, and A549 cancer cell lines.
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