Journal
NATURAL PRODUCT RESEARCH
Volume 36, Issue 4, Pages 1058-1061Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2020.1844695
Keywords
Echeveria subrigida; alpha-glucosidase inhibition; flavonoids; proanthocyanidins; tannins
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Funding
- National Council of Science and Technology of Mexico (CONACyT) [A1-S-24537, INFR-2011-3-173395]
- Programa de Fomento y Apoyo a Proyectos de Investigacion' (PROFAPI) of the Autonomous University of Sinaloa [2015/148]
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The methanol extract of Echeveria subrigida, a plant native to Mexico, has shown potential antidiabetic activity. The compounds quercetin-3-O-beta-glucoside, isorhamnetin-3-O-beta-glucoside, and dimers to heptamers proanthocyanidins were identified as the main contributors to the alpha-glucosidase inhibitory activity in the extract.
Echeveria subrigida is native to Mexico and its methanol extract (ME) shows relevant biological activities for human health, including the alpha-glucosidase inhibitory (alpha GI) activity that suggests its antidiabetic potential. Fractionation of the ME based on the alpha GI activity (IC50 in mu g/mL) showed that quercetin-3-O-beta-glucoside (131.1), isorhamnetin-3-O-beta-glucoside (166.4), and dimers to heptamers proanthocyanidins (9.6) were among the main responsible of alpha GI activity in the ME. The purified compounds showed better activity than acarbose (IC50 = 4426 mu g/mL).
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