Journal
NATURAL PRODUCT RESEARCH
Volume 36, Issue 5, Pages 1282-1287Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2020.1871342
Keywords
Sigesbeckia glabrescens Makino; ent-pimarane-type; diterpenoids; anti-inflammatory
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Funding
- National Key R&D Program of China [2017YFC1701200]
- National Natural Science Foundation of China [81374061, 81903789]
- China Postdoctoral Science Foundation [2020M670675]
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A chemical investigation of Sigesbeckia glabrescens Makino identified four compounds, including two previously undescribed compounds Sigesbeckia K (1) and Sigesbeckia L (2). The anti-inflammatory effects of these compounds showed potential inhibitory effects.
A chemical investigation of Sigesbeckia glabrescens Makino identified four compounds. On the basis of spectroscopic data, they were determined to be ent-pimarane-type diterpenoids and their analogues, among which were two previously undescribed compounds, Sigesbeckia K (1) and Sigesbeckia L (2). The anti-inflammatory effects of these compounds were evaluated by testing their inhibition of LPS-induced NO production in BV2 microglial cells, which revealed potential inhibitory effects with IC50 value at 62.56 mu M and compared with the positive control minocycline (IC50 32.84 mu M). [GRAPHICS] .
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