Journal
NANOTECHNOLOGY
Volume 32, Issue 17, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/1361-6528/abdbed
Keywords
liver cancer; D-galactose; gold nanorods; siGPC-3
Funding
- National Natural Science Foundation of China [81960113, 81673009]
- Science and technology project of Jiangxi Provincial Department of Education [GJJ180966]
- Science and technology plan of Jiangxi health and Family Planning Commission [20195664]
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The multi-functional nanostructure GAL-GNR-siGPC-3 can target and silence the GPC-3 gene, effectively inhibiting the progression of HCC through photothermal effects.
Tumor-specific targeted delivery is a major obstacle to clinical treatment of hepatocellular carcinoma (HCC). Here we have developed a novel multi-functional nanostructure GAL-GNR-siGPC-3, which consists of Galactose (GAL) as the HCC-targeting moiety, golden nanorods (GNR) as a framework to destroy tumor cells under laser irradiation, and siRNA of Glypican-3 (siGPC-3) which induce specifically gene silence of GPC-3 in HCC. Glypican-3 (GPC-3) gene is highly associated with HCC and is a new potential target for HCC therapy. On the other hand, Gal can specifically bind to the asialoglycoprotein receptor which is highly expressed on membrane of hepatoma cells. GAL and siGPC-3 can induce targeted silencing of GPC-3 gene in hepatoma cells. In vivo and in vitro results showed that GAL-GNR-siGPC-3 could significantly induce downregulation of GPC-3 gene and inhibit the progression of HCC. More notably, GAL-GNR-siGPC-3 could induce both GPC-3 gene silencing and photothermal effects, and the synergistic treatment of tumors was more effective than individual treatments. In summary, GAL-GNR-siGPC-3 achieved a synergistic outcome to the treatment of cancer, which opens up a new approach for the development of clinical therapies for HCC.
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