Journal
NANO TODAY
Volume 35, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.nantod.2020.100985
Keywords
Metal-organic frameworks; Post-synthetic infiltration; In situ encapsulation; Bioentity preservation; Enzymatic nanofactory
Categories
Funding
- National Key Research and Development Program of China [YS2020YFA090023]
- National Natural Science Foundation of China [22001054, 51773199]
- Medical and Health Research Project of Zhejiang Province [2020KY239]
- Hangzhou Overseas High-level Talent (Teams) Innovation and Entrepreneurship Program [4095C5062000604]
- Climbing Plan Project of Hangzhou Normal University
- Scientific Research Foundation for the Advanced Talents of Hangzhou Normal University
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Preservation of biological entities (e.g. DNA, enzymes, viruses, microorganisms, biochips, etc.) has presented great potential in industrial catalysis and biomedical engineering due to their enhanced structural stability and biological functionality. However, technology gaps still exist for achieving high encapsulation efficiency with low performance deterioration to provide a universal preservation method for biological entities. Metal-organic frameworks (MOFs) have been demonstrated as promising platforms for encapsulation of different bioentities for their structural diversity, versatile tailorability as well as ultrahigh loading capacity. This review comprehensively summarizes the recent progress for encapsulation of bioentity within MOF (bioentity@MOF) via post-synthetic infiltration or in situ encapsulation, and classifies into three sections: biomacromolecules, viruses and living organisms, and biological devices. MOF coating can not only behavior as protective porous exoskeletons to develop enzymatic nanoreactors that allow the access of small substrates through the narrow channel. The emergence of bio-decomposable MOFs can be also employed for preserving functional bioentities (e.g. bio-based therapeutics, clinical biomarkers, cells, viruses, diagnostic biochips, etc.) that can retain their original activities after MOF being eluted. Predictably, the MOF preservation technique might bring in the technical innovation in industrial and/or biomedical applications. (C) 2020 Elsevier Ltd. All rights reserved.
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