Journal
MOVEMENT DISORDERS
Volume 36, Issue 4, Pages 1010-1015Publisher
WILEY
DOI: 10.1002/mds.28423
Keywords
deep brain stimulation; subthalamic nucleus; Parkinson' s disease; verbal learning; proactive interference; retroactive interference
Categories
Ask authors/readers for more resources
This study examined the acute effects of STN-DBS on proactive interference (PI) and retroactive interference (RI) during verbal learning in Parkinson's disease patients. The results showed that stimulation increased PI but had no effect on RI, indicating a role of STN in inhibitory control during memory encoding or recall.
Background Proactive interference (PI) refers to the interference of previously learned materials with new learning and reflects the failure of inhibitory processes in memory. Retroactive interference (RI) refers to the unfavorable effect of new learning on the later recall of previously learned information. Although subthalamic nucleus deep brain stimulation (STN-DBS) does not affect global cognition in Parkinson's disease (PD), it has negative effects on specific aspects of cognition, including verbal fluency and executive inhibitory control of action.To this end, we set to test the acute effect of STN-DBS on PI and RI during verbal learning. Methods Twenty PD patients with STN-DBS were tested on the California Verbal Learning Test-II using an ON/OFF stimulation design. Results The results showed that stimulation increased PI ON stimulation (P = 0.012) but had no effect on RI (P = 0.816). Conclusions Our results extend the role of STN to the inhibitory control that is required during memory encoding or recall for prevention of PI. (c) 2020 International Parkinson and Movement Disorder Society
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available