Journal
MOLECULES
Volume 25, Issue 23, Pages -Publisher
MDPI
DOI: 10.3390/molecules25235526
Keywords
biological activity; biotransformation; glycyrrhetinic acid; oleanolic acid; ursolic acid
Funding
- Russian Foundation for Basic Research [20-34-90104]
- Russian Science Foundation [18-14-00140]
- Russian Federation Ministry of Education and Science [AAAA-A19-119112290008-4, AAAA-A18-118030790037-7, AAAA-A19-119112290010-7]
- Russian Science Foundation [18-14-00140] Funding Source: Russian Science Foundation
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Oleanane and ursane pentacyclic triterpenoids are secondary metabolites of plants found in various climatic zones and regions. This group of compounds is highly attractive due to their diverse biological properties and possible use as intermediates in the synthesis of new pharmacologically promising substances. By now, their antiviral, anti-inflammatory, antimicrobial, antitumor, and other activities have been confirmed. In the last decade, methods of microbial synthesis of these compounds and their further biotransformation using microorganisms are gaining much popularity. The present review provides clear evidence that industrial microbiology can be a promising way to obtain valuable pharmacologically active compounds in environmentally friendly conditions without processing huge amounts of plant biomass and using hazardous and expensive chemicals. This review summarizes data on distribution, microbial synthesis, and biological activities of native oleanane and ursane triterpenoids. Much emphasis is put on the processes of microbial transformation of selected oleanane and ursane pentacyclic triterpenoids and on the bioactivity assessment of the obtained derivatives.
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