Journal
MOLECULES
Volume 26, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/molecules26030559
Keywords
catechol; polymer; antimicrobial; reactive oxygen species
Funding
- National Institutes of Health [R15GM135875]
- Office of the Assistant Secretary of Defense for Health Affairs through the Defense Medical Research and Development Program [W81XWH1810610]
- Office of Naval Research [N00014-20-1-2230]
- National Science Foundation [DMR 2001076]
- U.S. Department of Defense (DOD) [W81XWH1810610] Funding Source: U.S. Department of Defense (DOD)
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This review explores catechol-based antimicrobial polymers that utilize various mechanisms such as surface anchoring, metal ion binding, and generation of reactive oxygen species to exert antimicrobial properties.
Catechol is a key constituent in mussel adhesive proteins and is responsible for strong adhesive property and crosslinking formation. Plant-based polyphenols are also capable of chemical interactions similar to those of catechol and are inherently antimicrobial. This review reports a series of catechol-based antimicrobial polymers classified according to their antimicrobial mechanisms. Catechol is utilized as a surface anchoring group for adhering monomers and polymers of known antimicrobial properties onto various types of surfaces. Additionally, catechol's ability to form strong complexes with metal ions and nanoparticles was utilized to sequester these antimicrobial agents into coatings and polymer matrices. During catechol oxidation, reactive oxygen species (ROS) is generated as a byproduct, and the use of the generated ROS for antimicrobial applications was also introduced. Finally, polymers that utilized the innate antimicrobial property of halogenated catechols and polyphenols were reviewed.
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