Aggregation, interaction and thermodynamic characteristics of cationic surfactant plus moxifloxacin hydrochloride mixture in aquatic solutions of mono-/di-hydroxy compounds

Herein, the interaction of the fourth-generation fluoroquinolone antibiotic drug, moxifloxacin hydrochloride (MFH), which is extensively used for the treatment of wider ranges of bacterial infections, like pneumonia, endocarditis, tuberculosis, and other complicated dermal lesions, and cetyltrimethylammonium bromide (CTAB, a cationic surfactant) has been observed by conductivity method in aqueous, alcoholic (C2H5OH, C3H7OH-2), and diol (C2H4(OH)(2), C3H6(OH)(2)) solutions. For all of the MFH + CTAB cases studied, the appearance of a critical micelle concentration (cmc) demonstrated that the micellar system is dependent on the variation of temperature and the concentration of different additives. A change in the value of cmc manifests the existence of strong interaction prevailing amongst MFH and CTAB molecules. In presence of alcohols/diols, the value of cmc for the MFH + CTAB system was found higher compared to those values obtained for the MFH + CTAB system carried out in H2O, which indicates a favourable micellization process. The values of counter-ion dissociation were also found to be dependent on temperature. The Delta G(m)(o) values were observed negative, which, again, manifests a spontaneous micellization process. The free energy of transfer and the enthalpy-entropy compensation were also calculated and discussed. [GRAPHICS]

Automated summary

The interaction between the antibiotic drug MFH and the surfactant CTAB was studied in different solvents, showing a strong dependence on temperature and concentration. The presence of alcohols/diols was found to facilitate micellization, with negative Delta G(m)(o) values indicating a spontaneous process. Additionally, the values of counter-ion dissociation were temperature-dependent.