The role of high mobility group protein B3 (HMGB3) in tumor proliferation and drug resistance

The high mobility group protein B (HMGB) family (including HMGB1, HMGB2, HMGB3, and HMGB4) can regulate the mechanisms of DNA replication, transcription, recombination, and repair, and act as cytokines to mediate responses to infection, injury, and inflammation. HMGB1/2/3 has a high similarity in sequence and structure, while HMGB4 has no acidic C-terminal tail. Among them, HMGB3 can regulate the self-renewal and differentiation of normal hematopoietic stem cell population, but the decrease of its expression is easy to induce leukemia. Up-regulation of its expression promotes tumor development and chemotherapy resistance through a variety of mechanisms, and non-coding RNA can regulate to promote tumor cell proliferation, invasion, and migration and inhibit cancer cell apoptosis.

Automated summary

The HMGB protein family, including HMGB1, HMGB2, HMGB3, and HMGB4, regulates DNA replication, transcription, recombination, and repair, and functions as cytokines mediating responses to infection, injury, and inflammation. Among them, HMGB3 plays a crucial role in regulating normal hematopoietic stem cells and its expression levels are closely related to leukemia development.