4.5 Review

Ferulic Acid and Cardiovascular Health: Therapeutic and Preventive Potential

Journal

MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 21, Issue 13, Pages 1625-1637

Publisher

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389557521666210105122841

Keywords

Natural product; foods; oxidative stress; antioxidant; cardioprotection; vasorelaxation

Funding

  1. National Council for Scientific and Technological Development (CNPq)
  2. Coordination for the Improvement of Higher Education Personnel (CAPES)

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Bioactive compounds found in food and medicinal plants play a crucial role in maintaining health and treating diseases. Ferulic acid, a hydroxycinnamic acid, possesses various pharmacological properties such as antioxidant and anti-inflammatory effects, and shows positive impact on the cardiovascular system.
Bioactive compounds found in food and medicinal plants contribute to maintaining health and treating illnesses. For example, hydroxycinnamic acids, such as ferulic acid, are widely present in nature and have several pharmacological properties, including antioxidant, anti-inflammatory, and beneficial effects in parameters of diabetes and hyperlipidemia. The results of studies in animal models and in vitro experiments of ferulic acid suggest its high therapeutic and preventive potential against several pathological disorders, such as cardiovascular diseases. Therefore, in this review, the bioactivities of ferulic acid on the cardiovascular system are described, including the discussion of the mechanisms of action in the various components of the system. In this review, we discuss the pharmacological properties of this versatile natural product in aspects of cardiovascular health, including cardioprotective and antihypertensive actions, and on the metabolism of lipids, diabetes, and thrombosis.

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