Journal
MICROCHEMICAL JOURNAL
Volume 159, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.microc.2020.105387
Keywords
Microbial species; Sample preparations; MALDI-TOF MS; Nanoparticles; Clinical samples
Categories
Funding
- Department of Science and Technology of the Government of India under the Extramural Research scheme of the Science and Engineering Research Board [EMR/2016/002621/IPC]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science and ICT [NRF-2018R1A4A1022647]
- Kwangwoon University
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Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has achieved considerable progress in bacterial analysis, allowing the identification of pathogenic microbial species at both species and genus level. This review analyzes the recent progress and implications of MALDI-TOF MS as a promising biotool for the rapid analysis of multiple pathogenic microbes in environmental and clinical samples. Nanoparticle (NP)-based MALDI-TOF MS methods for accurate bacterial analysis are also discussed. This review also summarizes sample preparation protocols and used matrix solutions in MALDI-TOF MS for the analysis of microbial species. Furthermore, we discuss the currently established advantages and limitations of MALDI-TOF MS in identifying microbial species.
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