Journal
MICROBIOLOGICAL RESEARCH
Volume 241, Issue -, Pages -Publisher
ELSEVIER GMBH
DOI: 10.1016/j.micres.2020.126591
Keywords
Salmonella; Secretion system; Host-pathogen interaction
Categories
Funding
- National Natural Science Foundation of China [NSFC 31700126, NSFC 81671980, 81871623, NSFC 81600034]
- China Postdoctoral Science Foundation [2017M611383]
- Heilongjiang Provincial Natural Science Foundation of China [LH2020H017]
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The bacterial genus Salmonella includes a large group of food-borne pathogens that cause a variety of gastro-intestinal or systemic diseases in hosts. Salmonella use several secretion devices to inject various effectors targeting eukaryotic hosts, or bacteria. In the past few years, considerable progress has been made towards understanding the structural features and molecular mechanisms of the secretion systems of Salmonella, particularly regarding their roles in host-pathogen interactions. In this review, we summarize the current advances about the main characteristics of the Salmonella secretion systems. Clarifying the roles of the secretion systems in the process of infecting various hosts will broaden our understanding of the importance of microbial interactions in maintaining human health and will provide information for developing novel therapeutic approaches.
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