4.2 Article

Carbapenem-Resistant Gram Negative Bacilli Are Predominantly Multidrug or Pan-Drug Resistant

Journal

MICROBIAL DRUG RESISTANCE
Volume 27, Issue 8, Pages 1057-1062

Publisher

MARY ANN LIEBERT, INC
DOI: 10.1089/mdr.2020.0294

Keywords

carbapenem-resistant; Gram negative bacilli; multidrug-resistant; pan-drug resistant; colistin

Ask authors/readers for more resources

Carbapenems were originally introduced against multidrug-resistant Gram-negative bacilli, but are now causing an increase in carbapenem-resistant strains due to initial empiric use. The carbapenem-resistant isolates show higher resistance to other antibiotics and majority are extended-spectrum beta-lactamase producers. Overall, carbapenem-resistant Gram-negative bacilli are predominantly multidrug-resistant or pan-drug resistant.
Carbapenems, although originally introduced against multidrug-resistant (MDR) Gram negative bacilli (GNB), are now advocated for initial empiric use resulting in increasing carbapenem-resistant (CR) GNB. In this study, we analyzed the frequencies of CR-GNB and compared their resistance patterns against other antibiotics. Overall, 42% (1,014/2,420) of CR-GNB were isolated (range: 29-59%), with similar frequencies among hospitalized and community-acquired infections. However, the CR frequencies in Acinetobacter baumannii were significantly higher in the hospitalized patients (>50%). In addition, the CR-GNB isolates showed significantly higher resistance to the other antibiotics-fluoroquinolones, aminoglycosides, sulfonamides, and ureidopenicillins compared to carbapenem-sensitive isolates, thereby limiting further treatment options. Majority of CR-GNB isolates were extended spectrum beta-lactamase producers (38-72%) and MDR (19-61%). Pan-drug resistant (PDR) frequencies among these MDR isolates ranged from 21% (Proteus spp.) to 100% (A. baumannii). Overall, CR-GNB are predominantly MDR or PDR and so warrant continuous antibiotic surveillance to provide better management of the infectious diseases.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.2
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available