Journal
DISEASE MODELS & MECHANISMS
Volume 9, Issue 11, Pages 1349-1355Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dmm.026674
Keywords
Herpes simplex virus; Amyloid beta aggregations; Alzheimer's disease; PCR detection; Human brain tissue; Paraffin-embedded samples
Categories
Funding
- Suomen Kulttuurirahasto Pirkanmaan Rahasto (Finnish Cultural Foundation Pirkanmaa Regional Fund)
- Company of Biologists (Disease Models Mechanisms)
- Vasterbotten Lans Landsting (Vasterbotten County Council)
- Kempestiftelserna (Kempe Foundations)
- Sveriges Lakarforbund (the Swedish Medical Association)
- Swedish Dementia Association
- Trolle-Wachtmeister Foundation
- Dementia Fund in Vasterbotten
- Swedish Alzheimer Fund
- Gun och Bertil Stohnes Stiftelse (Stohne Foundation)
- Magnus Bergvalls Stiftelse (Bergvall Foundation)
- Umea Universitet Foundation for Medical Research
Ask authors/readers for more resources
Herpes simplex virus (HSV) type 1 affects a majority of the population and recent evidence suggests involvement in Alzheimer's disease aetiology. We investigated the prevalence of HSV type 1 and 2 in the Tampere Autopsy Study (TASTY) brain samples using PCR and sero-positivity in plasma, and associations with Alzheimer's disease neuropathology. HSV was shown to be present in human brain tissue in 11/584 (1.9%) of samples in the TASTY cohort, of which six had Alzheimer's disease neuropathological amyloid beta (A beta) aggregations. Additionally, serological data revealed 86% of serum samples tested were IgG-positive for HSV. In conclusion, we report epidemiological evidence of the presence of HSV in brain tissue free from encephalitis symptoms in a cohort most closely representing the general population (a minimum prevalence of 1.9%). Whereas 6/11 samples with HSV DNA in the brain tissue had A beta aggregations, most of those with A beta aggregations did not have HSV present in the brain tissue.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available