4.5 Article

Influence of iron on growth and on susceptibility to itraconazole in Sporothrix spp.

Journal

MEDICAL MYCOLOGY
Volume 59, Issue 4, Pages 400-403

Publisher

OXFORD UNIV PRESS
DOI: 10.1093/mmy/myaa099

Keywords

Sporotrichosis; subcutaneous mycosis; deferasirox; itraconazole; iron

Funding

  1. Coordenacao de Aperfeicoamento de Pessoa de Nivel Superior (CAPES)
  2. Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)

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The growth of S. brasiliensis isolates was more affected by iron availability compared to S. schenckii, while both fungal species conidia became more prone to oxidative stress when exposed to iron in culture medium. However, the combination of itraconazole and deferasirox only resulted in synergism against a minority of S. schenckii isolates.
We evaluated the growth and the susceptibility to oxidative stress of Sporothrix spp., exposed to different iron concentrations in culture medium, and the susceptibility of Sporothrix spp. to itraconazole, alone and in combination with to the iron chelator deferasirox. The results showed that the growth of S. brasiliensis isolates was more affected by iron availability in comparison to S. schenckii, but both fungal species conidia became more prone to oxidative stress when iron was added to culture medium. Conversely, the combination of itraconazole and deferasirox only resulted in synergism against a minority of S. schenckii isolates.

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