Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 117, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.msec.2020.111265
Keywords
Bletilla striata polysaccharide; Hydrogel; Probiotics; Wound healing
Categories
Funding
- National Natural Science Foundation of China [81603309]
- National Key Research and Development Program of China [2017YFC1700705]
- Sichuan Provincial Scholars for Science and Technology Activities for Overseas Researchers [2018-68]
- Research Project of Sichuan Province [2020YFS0330, 2019YFS0174]
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As a new strategy for wound management, probiotics are highly sensitive to the external environment during use. In this study, an attempt is made to apply oxidized Bletilla striata polysaccharide (OBSP) hydrogel as a delivery system to put up a physical barrier to probiotics. Bletilla striata, as a famous traditional Chinese med-icine, has been widely used for over 1500 years to promote wound healing. Firstly, probiotic-bound OBSP-Chitosan composite hydrogel (OBSP-CS-LP hydrogel) was prepared by a simple and environmentally friendly approach. Subsequently, the SEM image, swelling and rheological properties of the OBSP-CS-LP hydrogel were investigated. Notably, composite probiotics to wounds are an attractive novel intervention that significantly improves the antibacterial properties of the hydrogel and avoids the pitfalls of many antibiotic therapies. Furthermore, the full-thickness skin defect model in vivo indicated an outstanding wound healing efficacy. Therefore, OBSP-CS-LP hydrogel could be applied as a promising dressing in the wound healing.
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