Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 118, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.msec.2020.111449
Keywords
Charge-convertible nanocarriers; CdSe@ZnS/ZnS QD; Protein delivery; Endo/lysosomal escape; Real-time imaging
Categories
Funding
- National Natural Science Foundation of China (NSFC) [21805108]
- Science and Technology Innovation Development Program of Jilin City [201831747, 201831749]
- Science and Technology Project of Jilin Provincial Education Department of China [JJKH20190821KJ]
- Outstanding Young Talents Program through a Science and Technology Development Plan Program of Jilin Province [20190103132JH]
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The study presents a pH-activated charge-convertible quantum dots-based nanocarrier, demonstrating its potential in drug delivery and bioimaging with promising tumor-targeting therapeutic effects.
The rapid developments of nanocarriers based on quantum dots (QDs) have been confirmed to show substantial promise for drug delivery and bioimaging. However, optimal QDs-based nanocarriers still need to have their controlled behavior in vitro and in vivo and decrease heavy metal-associated cytotoxicity. Herein, a pH-activated charge convertible QD-based nanocarrier was fabricated by capping multifunctional polypeptide ligands (mPEGblock-poly(ethylenediamine-dihydrolipoic acid-2,3-dimethylmaleic anhydride)-L-glutamate, PEG-P(ED-DLADMA)LG) onto the surface of core/multishell CdSe@ZnS/ZnS QD by means of a ligand exchange strategy, followed by uploading of cytochrome C (CC) (CC-loaded QD-PEG-P(ED-DLA-DMA)LG) via electrostatic interactions, in which QDs that were water-soluble and protein-loading were perfectly integrated. That is, the CC loaded QD-PEG-P(ED-DLA-DMA)LG inherited excellent fluorescence properties from CdSe@ZnS/ZnS QD for real-time imaging, as well as tumor-microenvironment sensitivities from PEG-P(ED-DLA-DMA)LG for enhanced cellular uptake and CC release. Experimental results verified that the QD-PEG-P(ED-DLA-DMA)LG showed enhanced internalization, rapid endo/lysosomal escape, and supplied legible real-time imaging for lung carcinoma cells. Furthermore, pH-triggered charge-convertible ability enabled the QD-PEG-P(ED-DLA-DMA)LG-CC to effectively kill cancer cells better than did the control groups. Hence, constructing smart nanocomposites by facile ligand-exchange strategy is beneficial to QD-based nanocarrier for tumor-targeting cancer therapy.
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