Journal
MARINE DRUGS
Volume 19, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/md19020055
Keywords
marine drugs; aurilides; depsipeptides; total synthesis; macrocyclization
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Funding
- Montpellier University
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Aurilides, a class of depsipeptides found mainly in marine cyanobacteria, have shown strong cytotoxicity against various cancer cell lines. Numerous studies on aurilides have emerged since 1996, summarizing both their biological activities and total syntheses of natural compounds and synthetic analogues.
Aurilides are a class of depsipeptides occurring mainly in marine cyanobacteria. Members of the aurilide family have shown to exhibit strong cytotoxicity against various cancer cell lines. These compounds bear a pentapeptide, a polyketide, and an alpha-hydroxy ester subunit in their structure. A large number of remarkable studies on aurilides have emerged since 1996. This comprehensive account summarizes the biological activities and total syntheses of natural compounds of the aurilide family as well as their synthetic analogues.
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