Journal
MARINE DRUGS
Volume 18, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/md18120608
Keywords
Aspergillus terreus; Aspergillus flocculosus; Penicillium sp; marine-derived fungi; South China Sea; secondary metabolites; asterriquinones; polyketides; neuroprotective activity; reactive oxygen species
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Funding
- Russian Foundation for Basic Research [19-53-54002]
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Low molecular weight secondary metabolites of marine fungi Aspergillus flocculosus, Aspergillus terreus and Penicillium sp. from Van Phong and Nha Trang Bays (Vietnam) were studied and a number of polyketides, bis-indole quinones and terpenoids were isolated. The structures of the isolated compounds were determined by 1D and 2D NMR and HR-ESI-MS techniques. Stereochemistry of some compounds was established based on ECD data. A chemical structure of asterriquinone F (6) was thoroughly described for the first time. Anthraquinone (13) was firstly obtained from a natural source. Neuroprotective influences of the isolated compounds against 6-OHDA, paraquat and rotenone toxicity were investigated. 4-Hydroxyscytalone (1), 4-hydroxy-6-dehydroxyscytalone (2) and demethylcitreoviranol (3) have shown significant increasing of paraquat- and rotenone-treated Neuro-2a cell viability and anti-ROS activity.
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