Journal
MACROMOLECULAR BIOSCIENCE
Volume 21, Issue 3, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.202000364
Keywords
FND; polycaprolactone; rGO; surgical site infection (SSI); suture; temperature sensing
Funding
- PSG Institutions, India
- RMIT Vice-Chancellor Fellowship
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The study incorporates functionalized nanodiamond and reduced graphene oxide into biodegradable polycaprolactone to develop a new multifunctional suture with temperature sensing capability and antibiotic coating function. The new suture enhances tensile strength and toughness, showing promise for monitoring and supporting wound closure.
The next-generation sutures should provide in situ monitoring of wound condition such as temperature while reducing surgical site infection during wound closure. In this study, functionalized nanodiamond (FND) and reduced graphene oxide (rGO) into biodegradable polycaprolactone (PCL) are incorporated to develop a new multifunctional suture with such capabilities. Incorporation of FND and rGO into PCL enhances its tensile strength by about 43% and toughness by 35%. The sutures show temperature sensing capability in the range of 25-40 degrees C based on the shift in zero-splitting frequency of the nitrogen-vacancy (NV-) centers in FND via optically detected magnetic resonance, paving the way for potential detection of infection or excessive inflammation in healing wounds. The suture surface readily coats with antibiotics to reduce bacterial infection risk to the wounds. The new suture thus is promising in monitoring and supporting wound closure.
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