Journal
LIFE SCIENCES
Volume 265, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2020.118756
Keywords
Atherosclerosis; Non-coding RNAs; Endothelial cells; VSMCs; Monocytes/macrophages
Funding
- National Natural Science Foundation of China [91739119, 81670406]
- Key Laboratory of Myocardial Ischemia, Ministry of Education [KF201813]
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Atherosclerosis is the primary culprit of cardiovascular and cerebrovascular diseases, and non-coding RNA plays a regulatory role in the development and progression of atherosclerosis.
Atherosclerosis is the primary culprit of cardiovascular and cerebrovascular diseases. Also, atherogenesis and the development of atherosclerosis involve endothelial cells, monocytes/macrophages, smooth myocytes, and others. Increasingly, studies have found that non-coding RNA (ncRNA) which can regulate apoptosis, pyroptosis, autophagy, proliferation, and monocyte migration participates in atherogenesis and progress of atherosclerosis by the above. The ncRNA networks may be essential in regulating the complicated process of atherosclerosis. Accordingly, this review delves into the regulatory roles of ncRNA, which were introduced previously. The answer above is particularly crucial to explain further the regulatory mechanism of ncRNA in cardiovascular disorders. Furthermore, we discuss the possibility and related research of ncRNAs as a biomarker and therapeutic target for the prevention, diagnosis, and treatment of atherosclerosis.
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