Journal
LETTERS IN ORGANIC CHEMISTRY
Volume 19, Issue 4, Pages 263-275Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1570178618666210119121438
Keywords
Antioxidant activity; dopamine receptors; indole derivatives; molecular modeling; Parkinson's disease; structural studies
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Funding
- Interdisciplinary Center for Mathematical and Computational Modeling (ICM), Warsaw, Poland [G30-18]
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Compound KAD22 was designed as a potential dopamine D2 receptor agonist with antioxidant activity for possible treatment of Parkinson's disease. Experimental and computational studies showed that KAD22 has potent antioxidant activity but no affinity to dopamine D2 receptor.
Compound KAD22 (5-methoxy-1-methyl-2-{[4-(2-hydroxyphenyl)piperazin-1-yl]methyl}1H-indole) was designed as a potential dopamine D2 receptor agonist with antioxidant activity for possible treatment of Parkinson's disease. The compound was obtained from 5-methoxy-1-methyl-1H-indole-2-carbaldehyde and 2-(piperazin-1-yl)phenol. KAD22 showed no affinity to dopamine D2 receptor but it is a potent antioxidant. Experimental and computational structural studies (conformational analysis, HOMO and LUMO orbitals, electrostatic potential map, non-covalent interaction plot, spectral properties, ligand-receptor interactions) of KAD22 were performed to address its biological activity.
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