Journal
LANGMUIR
Volume 37, Issue 1, Pages 339-347Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.langmuir.0c02930
Keywords
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Funding
- National Natural Science Foundation of China [21503276, 22072181]
- Fundamental Research Funds for the Central Universities [18CX02127A]
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A novel anticancer prodrug molecule was designed for targeted drug delivery, which could self-assemble into different nanostructures at different pH levels. The self-assemblies demonstrated good cancer cell selectivity, mainly due to their pH-responsive structural transition and folate active targeting effect.
Targeting delivery is a promising technique for the therapy of cancers. A molecule FA-EEYSV-NH2, which consists of target recognition site folic acid (FA), dipeptide linker, and peptide drug, was designed as a novel anticancer prodrug. The molecules could self-assemble into nanoparticles at pH 7.0 and nanofibers at pH 5.0. By the aid of pH-responsiveness, the self-assemblies were used purposefully as targeted vehicles of self-delivery prodrugs. The results of cell toxicity and internalization assays have proved that the self-assemblies have good cancer cell selectivity. The selection was mainly attributed to the pH-responsive structure transition of self-assemblies and the FA active-targeting effect. We hope that our work could provide a useful strategy for finely tuning the properties and activities of peptide-based supramolecular nanomaterials, thus optimizing nanomedicines with enhanced performance.
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