Journal
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
Volume 76, Issue 5, Pages 805-810Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glaa302
Keywords
Healthspan; Life span; Noncoding RNA; RNA-seq; Transposable elements
Categories
Funding
- National Institute on Aging [AG060302]
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The study shows that healthy aging interventions globally reduce transcripts of noncoding repetitive elements, while aging and high-fat diet increase their expression. The reduction of RE transcripts with healthy aging interventions is associated with biological/physiological processes linked to aging.
Transcripts from noncoding repetitive elements (REs) in the genome may be involved in aging. However, they are often ignored in transcriptome studies on healthspan and lifespan, and their role in healthy aging interventions has not been characterized. Here, we analyze REs in RNA-seq datasets from mice subjected to robust healthspan- and lifespan-increasing interventions including calorie restriction, rapamycin, acarbose, 17-alpha-estradiol, and Protandim. We also examine RE transcripts in long-lived transgenic mice, and in mice subjected to a high-fat diet, and we use RNA-seq to investigate the influence of aerobic exercise on RE transcripts with aging in humans. We find that (a) healthy aging interventions/behaviors globally reduce RE transcripts, whereas aging and high-fat diet (an age-accelerating treatment) increase RE expression; and (b) reduced RE expression with healthy aging interventions is associated with biological/physiological processes mechanistically linked with aging. Our results suggest that RE transcript dysregulation and suppression are likely novel mechanisms underlying aging and healthy aging interventions, respectively.
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