Journal
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
Volume 113, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jmbbm.2020.104154
Keywords
Collagen; Remodeling; Fibers; Morphoelasticity; Homeostasis
Funding
- NPRP grant from the Qatar National Research Fund (a member of the Qatar Foundation) [8-2424-1-477]
Ask authors/readers for more resources
The study explores the creation and maintenance of collagen in biological tissue, emphasizing the morphoelastic changes under mechanical stimuli. The model uses fiber density evolution to represent the fiber structure, with considerations for different natural configurations and finite survival times.
A variety of biochemical and physical processes participate in the creation and maintenance of collagen in biological tissue. Under mechanical stimuli these collagen fibers undergo continuous processes of morphoelastic change. The model presented here is motivated by experimental reports of stretch-stabilization of the collagen fibers to enzymatic degradation. The fiber structure is modeled in terms of a fiber density evolution that is regulated by means of a fixed creation rate and a mechano-sensitive dissolution rate. The theory accounts for the possibly different natural configurations of the fiber unit constituents and the ground substance matrix. It also generalizes previous theoretical descriptions so as to account for finite survival times of the individual fiber units. Special consideration is given to steady state fiber-remodeling processes in which fiber creation and dissolution are in balance. Fiber assembly processes that involve prestretching the fiber constituents yield a homeostatic stress response with a characteristic fiber tone. Fiber density returns to homeostasis after mechanical disruption when sufficient time has passed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available